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Hit-to-Lead: Hit Validation and Assessment.
Hevener KE, Pesavento R, Ren J, Lee H, Ratia K, Johnson ME. Hevener KE, et al. Methods Enzymol. 2018;610:265-309. doi: 10.1016/bs.mie.2018.09.022. Epub 2018 Oct 25. Methods Enzymol. 2018. PMID: 30390802
High-throughput screening (HTS) and hit validation to identify small molecule inhibitors with activity against NS3/4A proteases from multiple hepatitis C virus genotypes.
Lee H, Zhu T, Patel K, Zhang YY, Truong L, Hevener KE, Gatuz JL, Subramanya G, Jeong HY, Uprichard SL, Johnson ME. Lee H, et al. Among authors: hevener ke. PLoS One. 2013 Oct 9;8(10):e75144. doi: 10.1371/journal.pone.0075144. eCollection 2013. PLoS One. 2013. PMID: 24130685 Free PMC article.
Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI).
Mehboob S, Song J, Hevener KE, Su PC, Boci T, Brubaker L, Truong L, Mistry T, Deng J, Cook JL, Santarsiero BD, Ghosh AK, Johnson ME. Mehboob S, et al. Among authors: hevener ke. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1292-6. doi: 10.1016/j.bmcl.2015.01.048. Epub 2015 Jan 29. Bioorg Med Chem Lett. 2015. PMID: 25677657 Free PMC article.
44 results