Hoffmann M - Search Results

1

In vitro inhibition of human nucleoside transporters and uptake of azacitidine by an isocitrate dehydrogenase-2 inhibitor enasidenib and its metabolite AGI-16903.

Tong Z, Yerramilli U, Yao S, Young JD, Hoffmann M, Surapaneni S. Tong Z, et al. Among authors: hoffmann m. Xenobiotica. 2019 Oct;49(10):1229-1236. doi: 10.1080/00498254.2018.1539783. Epub 2018 Nov 29. Xenobiotica. 2019. PMID: 30394160

2

Absorption, distribution, metabolism and excretion of an isocitrate dehydrogenase-2 inhibitor enasidenib in rats and humans.

Tong Z, Atsriku C, Yerramilli U, Wang X, Li Y, Reyes J, Fan B, Yang H, Hoffmann M, Surapaneni S. Tong Z, et al. Among authors: hoffmann m. Xenobiotica. 2019 Feb;49(2):200-210. doi: 10.1080/00498254.2018.1425511. Epub 2018 Jan 22. Xenobiotica. 2019. PMID: 29320949

3

Disposition, metabolism and mass balance of [(14)C]apremilast following oral administration.

Hoffmann M, Kumar G, Schafer P, Cedzik D, Capone L, Fong KL, Gu Z, Heller D, Feng H, Surapaneni S, Laskin O, Wu A. Hoffmann M, et al. Xenobiotica. 2011 Dec;41(12):1063-75. doi: 10.3109/00498254.2011.604745. Epub 2011 Aug 23. Xenobiotica. 2011. PMID: 21859393 Free PMC article. Clinical Trial.

4

In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism.

Atsriku C, Hoffmann M, Moghaddam M, Kumar G, Surapaneni S. Atsriku C, et al. Among authors: hoffmann m. Xenobiotica. 2015;45(6):465-80. doi: 10.3109/00498254.2014.991367. Epub 2014 Dec 5. Xenobiotica. 2015. PMID: 25475995

5

Assessment of drug-drug interactions of CC-90001, a potent and selective inhibitor of c-Jun N-terminal kinase.

Tong Z, Gaudy A, Tatosian D, Ramirez-Valle F, Liu H, Chen J, Hoffmann M, Surapaneni S. Tong Z, et al. Among authors: hoffmann m. Xenobiotica. 2021 Dec;51(12):1416-1426. doi: 10.1080/00498254.2022.2027553. Epub 2022 Jan 13. Xenobiotica. 2021. PMID: 35000550

6

The Uremic Toxin Indoxyl-3-Sulfate Induces CYP1A2 In Primary Human Hepatocytes.

Liu H, Narayanan R, Hoffmann M, Surapaneni S. Liu H, et al. Among authors: hoffmann m. Drug Metab Lett. 2016;10(3):195-199. doi: 10.2174/1872312810666160719143703. Drug Metab Lett. 2016. PMID: 27449409

7

Metabolism and disposition of a potent and selective JNK inhibitor [14C]tanzisertib following oral administration to rats, dogs and humans.

Atsriku C, Hoffmann M, Ye Y, Kumar G, Surapaneni S. Atsriku C, et al. Among authors: hoffmann m. Xenobiotica. 2015 May;45(5):428-41. doi: 10.3109/00498254.2014.990949. Epub 2014 Dec 8. Xenobiotica. 2015. PMID: 25482583 Clinical Trial.

8

Use of 4β-hydroxycholesterol in animal and human plasma samples as a biomarker for CYP3A induction.

Xue YJ, Hoffmann M, Tong Z, Wu XI, Vallejo M, Melo B, Ye Y, Thomas M, Liu Y, Weiss D, Surapaneni S. Xue YJ, et al. Among authors: hoffmann m. Bioanalysis. 2016 Feb;8(3):215-28. doi: 10.4155/bio.15.241. Epub 2016 Jan 25. Bioanalysis. 2016. PMID: 26805594

9

Application of a "Fit for Purpose" PBPK Model to Investigate the CYP3A4 Induction Potential of Enzalutamide.

Narayanan R, Hoffmann M, Kumar G, Surapaneni S. Narayanan R, et al. Among authors: hoffmann m. Drug Metab Lett. 2016;10(3):172-179. doi: 10.2174/1872312810666160729124745. Drug Metab Lett. 2016. PMID: 27604990

10

Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration.

Hoffmann M, Kasserra C, Reyes J, Schafer P, Kosek J, Capone L, Parton A, Kim-Kang H, Surapaneni S, Kumar G. Hoffmann M, et al. Cancer Chemother Pharmacol. 2013 Feb;71(2):489-501. doi: 10.1007/s00280-012-2040-6. Epub 2012 Dec 1. Cancer Chemother Pharmacol. 2013. PMID: 23203815 Free PMC article. Clinical Trial.

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