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Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists.
Liu H, Hofmann J, Fish I, Schaake B, Eitel K, Bartuschat A, Kaindl J, Rampp H, Banerjee A, Hübner H, Clark MJ, Vincent SG, Fisher JT, Heinrich MR, Hirata K, Liu X, Sunahara RK, Shoichet BK, Kobilka BK, Gmeiner P. Liu H, et al. Among authors: hirata k. Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12046-12050. doi: 10.1073/pnas.1813988115. Epub 2018 Nov 7. Proc Natl Acad Sci U S A. 2018. PMID: 30404914 Free PMC article.
Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.
Jiang X, Smirnova I, Kasho V, Wu J, Hirata K, Ke M, Pardon E, Steyaert J, Yan N, Kaback HR. Jiang X, et al. Among authors: hirata k. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12420-12425. doi: 10.1073/pnas.1615414113. Epub 2016 Oct 19. Proc Natl Acad Sci U S A. 2016. PMID: 27791182 Free PMC article.
Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor.
Suno R, Lee S, Maeda S, Yasuda S, Yamashita K, Hirata K, Horita S, Tawaramoto MS, Tsujimoto H, Murata T, Kinoshita M, Yamamoto M, Kobilka BK, Vaidehi N, Iwata S, Kobayashi T. Suno R, et al. Among authors: hirata k. Nat Chem Biol. 2018 Dec;14(12):1150-1158. doi: 10.1038/s41589-018-0152-y. Epub 2018 Nov 12. Nat Chem Biol. 2018. PMID: 30420692 Free PMC article.
Structural Insights into the Process of GPCR-G Protein Complex Formation.
Liu X, Xu X, Hilger D, Aschauer P, Tiemann JKS, Du Y, Liu H, Hirata K, Sun X, Guixà-González R, Mathiesen JM, Hildebrand PW, Kobilka BK. Liu X, et al. Among authors: hirata k. Cell. 2019 May 16;177(5):1243-1251.e12. doi: 10.1016/j.cell.2019.04.021. Epub 2019 May 9. Cell. 2019. PMID: 31080070 Free PMC article.
Mechanism of β2AR regulation by an intracellular positive allosteric modulator.
Liu X, Masoudi A, Kahsai AW, Huang LY, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B. Liu X, et al. Among authors: hirata k. Science. 2019 Jun 28;364(6447):1283-1287. doi: 10.1126/science.aaw8981. Epub 2019 Jun 27. Science. 2019. PMID: 31249059 Free PMC article.
Crystal structure of the M5 muscarinic acetylcholine receptor.
Vuckovic Z, Gentry PR, Berizzi AE, Hirata K, Varghese S, Thompson G, van der Westhuizen ET, Burger WAC, Rahmani R, Valant C, Langmead CJ, Lindsley CW, Baell JB, Tobin AB, Sexton PM, Christopoulos A, Thal DM. Vuckovic Z, et al. Among authors: hirata k. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):26001-26007. doi: 10.1073/pnas.1914446116. Epub 2019 Nov 26. Proc Natl Acad Sci U S A. 2019. PMID: 31772027 Free PMC article.
An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor.
Liu X, Kaindl J, Korczynska M, Stößel A, Dengler D, Stanek M, Hübner H, Clark MJ, Mahoney J, Matt RA, Xu X, Hirata K, Shoichet BK, Sunahara RK, Kobilka BK, Gmeiner P. Liu X, et al. Among authors: hirata k. Nat Chem Biol. 2020 Jul;16(7):749-755. doi: 10.1038/s41589-020-0549-2. Epub 2020 Jun 1. Nat Chem Biol. 2020. PMID: 32483378 Free PMC article.
4,353 results