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Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists.
Liu H, Hofmann J, Fish I, Schaake B, Eitel K, Bartuschat A, Kaindl J, Rampp H, Banerjee A, Hübner H, Clark MJ, Vincent SG, Fisher JT, Heinrich MR, Hirata K, Liu X, Sunahara RK, Shoichet BK, Kobilka BK, Gmeiner P. Liu H, et al. Among authors: rampp h. Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12046-12050. doi: 10.1073/pnas.1813988115. Epub 2018 Nov 7. Proc Natl Acad Sci U S A. 2018. PMID: 30404914 Free PMC article.
Regiospecific Introduction of Halogens on the 2-Aminobiphenyl Subunit Leading to Highly Potent and Selective M3 Muscarinic Acetylcholine Receptor Antagonists and Weak Inverse Agonists.
Fischer O, Hofmann J, Rampp H, Kaindl J, Pratsch G, Bartuschat A, Taudte RV, Fromm MF, Hübner H, Gmeiner P, Heinrich MR. Fischer O, et al. Among authors: rampp h. J Med Chem. 2020 Apr 23;63(8):4349-4369. doi: 10.1021/acs.jmedchem.0c00297. Epub 2020 Apr 9. J Med Chem. 2020. PMID: 32202101