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Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes.
Jiao Y, Davis JE, Rautela J, Carrington EM, Ludford-Menting MJ, Goh W, Delconte RB, Souza-Fonseca-Guimaraes F, Koldej R, Gray D, Huang D, Kile BT, Lew AM, Ritchie DS, Huntington ND. Jiao Y, et al. Among authors: kile bt. Cell Death Differ. 2019 Aug;26(8):1516-1530. doi: 10.1038/s41418-018-0228-y. Epub 2018 Nov 12. Cell Death Differ. 2019. PMID: 30420758 Free PMC article.
Mechanisms of cellular crosstalk in the gastric tumor microenvironment are mediated by YAP1 and STAT3.
Thilakasiri P, O'Keefe RN, To SQ, Chisanga D, Eissmann MF, Carli AL, Duscio B, Baloyan D, Dmello RS, Williams D, Mariadason J, Poh AR, Pal B, Kile BT, Vissers JH, Harvey KF, Buchert M, Shi W, Ernst M, Chand AL. Thilakasiri P, et al. Among authors: kile bt. Life Sci Alliance. 2023 Nov 13;7(2):e202302411. doi: 10.26508/lsa.202302411. Print 2024 Feb. Life Sci Alliance. 2023. PMID: 37957015 Free PMC article.
Programmed anuclear cell death delimits platelet life span.
Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S, Kelly PN, Ekert PG, Metcalf D, Roberts AW, Huang DC, Kile BT. Mason KD, et al. Among authors: kile bt. Cell. 2007 Mar 23;128(6):1173-86. doi: 10.1016/j.cell.2007.01.037. Cell. 2007. PMID: 17382885 Free article.
Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development.
Kelly PN, White MJ, Goschnick MW, Fairfax KA, Tarlinton DM, Kinkel SA, Bouillet P, Adams JM, Kile BT, Strasser A. Kelly PN, et al. Among authors: kile bt. Cell Death Differ. 2010 Oct;17(10):1655-64. doi: 10.1038/cdd.2010.43. Epub 2010 Apr 30. Cell Death Differ. 2010. PMID: 20431598 Free PMC article.
Transgenic, inducible RNAi in megakaryocytes and platelets in mice.
Takiguchi M, James C, Josefsson EC, Carmichael CL, Premsrirut PK, Lowe SW, Hamilton JR, Huang DC, Kile BT, Dickins RA. Takiguchi M, et al. Among authors: kile bt. J Thromb Haemost. 2010 Dec;8(12):2751-6. doi: 10.1111/j.1538-7836.2010.04077.x. J Thromb Haemost. 2010. PMID: 21138522 Free PMC article.
Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets.
Schoenwaelder SM, Jarman KE, Gardiner EE, Hua M, Qiao J, White MJ, Josefsson EC, Alwis I, Ono A, Willcox A, Andrews RK, Mason KD, Salem HH, Huang DC, Kile BT, Roberts AW, Jackson SP. Schoenwaelder SM, et al. Among authors: kile bt. Blood. 2011 Aug 11;118(6):1663-74. doi: 10.1182/blood-2011-04-347849. Epub 2011 Jun 14. Blood. 2011. PMID: 21673344 Free article.
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.
Josefsson EC, James C, Henley KJ, Debrincat MA, Rogers KL, Dowling MR, White MJ, Kruse EA, Lane RM, Ellis S, Nurden P, Mason KD, O'Reilly LA, Roberts AW, Metcalf D, Huang DC, Kile BT. Josefsson EC, et al. Among authors: kile bt. J Exp Med. 2011 Sep 26;208(10):2017-31. doi: 10.1084/jem.20110750. Epub 2011 Sep 12. J Exp Med. 2011. PMID: 21911424 Free PMC article.
Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor.
Lindqvist LM, Vikström I, Chambers JM, McArthur K, Ann Anderson M, Henley KJ, Happo L, Cluse L, Johnstone RW, Roberts AW, Kile BT, Croker BA, Burns CJ, Rizzacasa MA, Strasser A, Huang DC. Lindqvist LM, et al. Among authors: kile bt. Cell Death Dis. 2012 Oct 11;3(10):e409. doi: 10.1038/cddis.2012.149. Cell Death Dis. 2012. PMID: 23059828 Free PMC article.
152 results