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Aging-dependent reduction in glyoxalase 1 delays wound healing.
Fleming TH, Theilen TM, Masania J, Wunderle M, Karimi J, Vittas S, Bernauer R, Bierhaus A, Rabbani N, Thornalley PJ, Kroll J, Tyedmers J, Nawrotzki R, Herzig S, Brownlee M, Nawroth PP. Fleming TH, et al. Among authors: nawroth pp. Gerontology. 2013;59(5):427-37. doi: 10.1159/000351628. Epub 2013 Jun 22. Gerontology. 2013. PMID: 23797271
Methylglyoxal accumulation de-regulates HoxA5 expression, thereby impairing angiogenesis in glyoxalase 1 knock-down mouse aortic endothelial cells.
Nigro C, Leone A, Longo M, Prevenzano I, Fleming TH, Nicolò A, Parrillo L, Spinelli R, Formisano P, Nawroth PP, Beguinot F, Miele C. Nigro C, et al. Among authors: nawroth pp. Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):73-85. doi: 10.1016/j.bbadis.2018.10.014. Epub 2018 Oct 18. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30342159 Free article.
The combination of loss of glyoxalase1 and obesity results in hyperglycemia.
Lodd E, Wiggenhauser LM, Morgenstern J, Fleming TH, Poschet G, Büttner M, Tabler CT, Wohlfart DP, Nawroth PP, Kroll J. Lodd E, et al. Among authors: nawroth pp. JCI Insight. 2019 Jun 20;4(12):e126154. doi: 10.1172/jci.insight.126154. eCollection 2019 Jun 20. JCI Insight. 2019. PMID: 31217350 Free PMC article.
Effect of metformin on methylglyoxal metabolism in patients with type 2 diabetes.
Kender Z, Fleming T, Kopf S, Torzsa P, Grolmusz V, Herzig S, Schleicher E, Rácz K, Reismann P, Nawroth PP. Kender Z, et al. Among authors: nawroth pp. Exp Clin Endocrinol Diabetes. 2014 May;122(5):316-9. doi: 10.1055/s-0034-1371818. Epub 2014 Apr 7. Exp Clin Endocrinol Diabetes. 2014. PMID: 24710646 Clinical Trial.
604 results