Spencer J - Search Results

1

Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases.

Salimraj R, Hinchliffe P, Kosmopoulou M, Tyrrell JM, Brem J, van Berkel SS, Verma A, Owens RJ, McDonough MA, Walsh TR, Schofield CJ, Spencer J. Salimraj R, et al. Among authors: spencer j. FEBS J. 2019 Jan;286(1):169-183. doi: 10.1111/febs.14695. Epub 2018 Nov 23. FEBS J. 2019. PMID: 30430727 Free PMC article.

2

Overexpression, purification, and characterization of the cloned metallo-beta-lactamase L1 from Stenotrophomonas maltophilia.

Crowder MW, Walsh TR, Banovic L, Pettit M, Spencer J. Crowder MW, et al. Among authors: spencer j. Antimicrob Agents Chemother. 1998 Apr;42(4):921-6. doi: 10.1128/AAC.42.4.921. Antimicrob Agents Chemother. 1998. PMID: 9559809 Free PMC article.

3

The crystal structure of the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia at 1.7 A resolution.

Ullah JH, Walsh TR, Taylor IA, Emery DC, Verma CS, Gamblin SJ, Spencer J. Ullah JH, et al. Among authors: spencer j. J Mol Biol. 1998 Nov 20;284(1):125-36. doi: 10.1006/jmbi.1998.2148. J Mol Biol. 1998. PMID: 9811546

4

Novel mechanism of hydrolysis of therapeutic beta-lactams by Stenotrophomonas maltophilia L1 metallo-beta-lactamase.

Spencer J, Clarke AR, Walsh TR. Spencer J, et al. J Biol Chem. 2001 Sep 7;276(36):33638-44. doi: 10.1074/jbc.M105550200. Epub 2001 Jul 6. J Biol Chem. 2001. PMID: 11443136 Free article.

5

Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases.

Buynak JD, Chen H, Vogeti L, Gadhachanda VR, Buchanan CA, Palzkill T, Shaw RW, Spencer J, Walsh TR. Buynak JD, et al. Among authors: spencer j. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1299-304. doi: 10.1016/j.bmcl.2003.12.037. Bioorg Med Chem Lett. 2004. PMID: 14980686

6

Over-expression, purification, and characterization of metallo-beta-lactamase ImiS from Aeromonas veronii bv. sobria.

Crawford PA, Sharma N, Chandrasekar S, Sigdel T, Walsh TR, Spencer J, Crowder MW. Crawford PA, et al. Among authors: spencer j. Protein Expr Purif. 2004 Aug;36(2):272-9. doi: 10.1016/j.pep.2004.04.017. Protein Expr Purif. 2004. PMID: 15249050

7

Antibiotic recognition by binuclear metallo-beta-lactamases revealed by X-ray crystallography.

Spencer J, Read J, Sessions RB, Howell S, Blackburn GM, Gamblin SJ. Spencer J, et al. J Am Chem Soc. 2005 Oct 19;127(41):14439-44. doi: 10.1021/ja0536062. J Am Chem Soc. 2005. PMID: 16218639

8

A new approach to the inhibition of metallo-beta-lactamases.

Spencer J, Walsh TR. Spencer J, et al. Angew Chem Int Ed Engl. 2006 Feb 6;45(7):1022-6. doi: 10.1002/anie.200502984. Angew Chem Int Ed Engl. 2006. PMID: 16404761 Review. No abstract available.

9

Crystal structure of Pseudomonas aeruginosa SPM-1 provides insights into variable zinc affinity of metallo-beta-lactamases.

Murphy TA, Catto LE, Halford SE, Hadfield AT, Minor W, Walsh TR, Spencer J. Murphy TA, et al. Among authors: spencer j. J Mol Biol. 2006 Mar 31;357(3):890-903. doi: 10.1016/j.jmb.2006.01.003. Epub 2006 Jan 23. J Mol Biol. 2006. PMID: 16460758

10

Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family.

Samuelsen Ø, Castanheira M, Walsh TR, Spencer J. Samuelsen Ø, et al. Among authors: spencer j. Antimicrob Agents Chemother. 2008 Aug;52(8):2905-8. doi: 10.1128/AAC.00166-08. Epub 2008 Jun 16. Antimicrob Agents Chemother. 2008. PMID: 18559652 Free PMC article.

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