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mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.
Melemedjian OK, Khoutorsky A, Sorge RE, Yan J, Asiedu MN, Valdez A, Ghosh S, Dussor G, Mogil JS, Sonenberg N, Price TJ. Melemedjian OK, et al. Among authors: price tj. Pain. 2013 Jul;154(7):1080-91. doi: 10.1016/j.pain.2013.03.021. Epub 2013 Mar 15. Pain. 2013. PMID: 23607966 Free PMC article.
Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes.
Gkogkas CG, Khoutorsky A, Cao R, Jafarnejad SM, Prager-Khoutorsky M, Giannakas N, Kaminari A, Fragkouli A, Nader K, Price TJ, Konicek BW, Graff JR, Tzinia AK, Lacaille JC, Sonenberg N. Gkogkas CG, et al. Among authors: price tj. Cell Rep. 2014 Dec 11;9(5):1742-1755. doi: 10.1016/j.celrep.2014.10.064. Epub 2014 Nov 26. Cell Rep. 2014. PMID: 25466251 Free PMC article.
The MNK-eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain.
Moy JK, Khoutorsky A, Asiedu MN, Black BJ, Kuhn JL, Barragán-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio JJ, Mogil JS, Dussor G, Sonenberg N, Price TJ. Moy JK, et al. Among authors: price tj. J Neurosci. 2017 Aug 2;37(31):7481-7499. doi: 10.1523/JNEUROSCI.0220-17.2017. Epub 2017 Jul 3. J Neurosci. 2017. PMID: 28674170 Free PMC article.
Translational Control Mechanisms in Persistent Pain.
Khoutorsky A, Price TJ. Khoutorsky A, et al. Among authors: price tj. Trends Neurosci. 2018 Feb;41(2):100-114. doi: 10.1016/j.tins.2017.11.006. Trends Neurosci. 2018. PMID: 29249459 Free PMC article. Review.
Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain.
Megat S, Ray PR, Moy JK, Lou TF, Barragán-Iglesias P, Li Y, Pradhan G, Wanghzou A, Ahmad A, Burton MD, North RY, Dougherty PM, Khoutorsky A, Sonenberg N, Webster KR, Dussor G, Campbell ZT, Price TJ. Megat S, et al. Among authors: price tj. J Neurosci. 2019 Jan 16;39(3):393-411. doi: 10.1523/JNEUROSCI.2661-18.2018. Epub 2018 Nov 20. J Neurosci. 2019. PMID: 30459229 Free PMC article.
443 results