Mansour WY - Search Results

1

A functional ex vivo assay to detect PARP1-EJ repair and radiosensitization by PARP-inhibitor in prostate cancer.

Köcher S, Beyer B, Lange T, Nordquist L, Volquardsen J, Burdak-Rothkamm S, Schlomm T, Petersen C, Rothkamm K, Mansour WY. Köcher S, et al. Among authors: mansour wy. Int J Cancer. 2019 Apr 1;144(7):1685-1696. doi: 10.1002/ijc.32018. Epub 2019 Jan 5. Int J Cancer. 2019. PMID: 30478958

2

The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair.

Kasten-Pisula U, Menegakis A, Brammer I, Borgmann K, Mansour WY, Degenhardt S, Krause M, Schreiber A, Dahm-Daphi J, Petersen C, Dikomey E, Baumann M. Kasten-Pisula U, et al. Among authors: mansour wy. Radiother Oncol. 2009 Feb;90(2):257-64. doi: 10.1016/j.radonc.2008.10.019. Epub 2008 Nov 27. Radiother Oncol. 2009. PMID: 19038467

3

The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies.

Mansour WY, Rhein T, Dahm-Daphi J. Mansour WY, et al. Nucleic Acids Res. 2010 Oct;38(18):6065-77. doi: 10.1093/nar/gkq387. Epub 2010 May 18. Nucleic Acids Res. 2010. PMID: 20483915 Free PMC article.

4

Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase.

Köcher S, Rieckmann T, Rohaly G, Mansour WY, Dikomey E, Dornreiter I, Dahm-Daphi J. Köcher S, et al. Among authors: mansour wy. Nucleic Acids Res. 2012 Sep 1;40(17):8336-47. doi: 10.1093/nar/gks604. Epub 2012 Jun 22. Nucleic Acids Res. 2012. PMID: 22730303 Free PMC article.

5

Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma.

Mansour WY, Bogdanova NV, Kasten-Pisula U, Rieckmann T, Köcher S, Borgmann K, Baumann M, Krause M, Petersen C, Hu H, Gatti RA, Dikomey E, Dörk T, Dahm-Daphi J. Mansour WY, et al. Radiother Oncol. 2013 Jan;106(1):147-54. doi: 10.1016/j.radonc.2012.10.020. Epub 2012 Nov 28. Radiother Oncol. 2013. PMID: 23199656

6

The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining.

Mansour WY, Borgmann K, Petersen C, Dikomey E, Dahm-Daphi J. Mansour WY, et al. DNA Repair (Amst). 2013 Dec;12(12):1134-42. doi: 10.1016/j.dnarep.2013.10.005. Epub 2013 Nov 7. DNA Repair (Amst). 2013. PMID: 24210699

7

Inhibition of PARP1-dependent end-joining contributes to Olaparib-mediated radiosensitization in tumor cells.

Kötter A, Cornils K, Borgmann K, Dahm-Daphi J, Petersen C, Dikomey E, Mansour WY. Kötter A, et al. Among authors: mansour wy. Mol Oncol. 2014 Dec;8(8):1616-25. doi: 10.1016/j.molonc.2014.06.008. Epub 2014 Jul 1. Mol Oncol. 2014. PMID: 25028150 Free PMC article.

8

Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation.

Bakr A, Oing C, Köcher S, Borgmann K, Dornreiter I, Petersen C, Dikomey E, Mansour WY. Bakr A, et al. Among authors: mansour wy. Nucleic Acids Res. 2015 Mar 31;43(6):3154-66. doi: 10.1093/nar/gkv160. Epub 2015 Mar 9. Nucleic Acids Res. 2015. PMID: 25753674 Free PMC article.

9

High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation.

Parplys AC, Seelbach JI, Becker S, Behr M, Wrona A, Jend C, Mansour WY, Joosse SA, Stuerzbecher HW, Pospiech H, Petersen C, Dikomey E, Borgmann K. Parplys AC, et al. Among authors: mansour wy. Cell Cycle. 2015;14(19):3190-202. doi: 10.1080/15384101.2015.1055996. Cell Cycle. 2015. PMID: 26317153 Free PMC article.

10

Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice.

Bakr A, Köcher S, Volquardsen J, Reimer R, Borgmann K, Dikomey E, Rothkamm K, Mansour WY. Bakr A, et al. Among authors: mansour wy. Radiother Oncol. 2016 May;119(2):276-81. doi: 10.1016/j.radonc.2015.11.001. Epub 2015 Nov 23. Radiother Oncol. 2016. PMID: 26615718

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