Hurdle JG - Search Results

1

The Fatty Acid Synthesis Protein Enoyl-ACP Reductase II (FabK) is a Target for Narrow-Spectrum Antibacterials for Clostridium difficile Infection.

Marreddy RKR, Wu X, Sapkota M, Prior AM, Jones JA, Sun D, Hevener KE, Hurdle JG. Marreddy RKR, et al. Among authors: hurdle jg. ACS Infect Dis. 2019 Feb 8;5(2):208-217. doi: 10.1021/acsinfecdis.8b00205. Epub 2018 Dec 13. ACS Infect Dis. 2019. PMID: 30501172 Free PMC article.

2

Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity.

Sun D, Scherman MS, Jones V, Hurdle JG, Woolhiser LK, Knudson SE, Lenaerts AJ, Slayden RA, McNeil MR, Lee RE. Sun D, et al. Among authors: hurdle jg. Bioorg Med Chem. 2009 May 15;17(10):3588-94. doi: 10.1016/j.bmc.2009.04.005. Epub 2009 Apr 9. Bioorg Med Chem. 2009. PMID: 19386501 Free PMC article.

3

Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections.

Hurdle JG, Yendapally R, Sun D, Lee RE. Hurdle JG, et al. Antimicrob Agents Chemother. 2009 Sep;53(9):4028-31. doi: 10.1128/AAC.00457-09. Epub 2009 Jul 6. Antimicrob Agents Chemother. 2009. PMID: 19581456 Free PMC article.

4

Structural studies of pterin-based inhibitors of dihydropteroate synthase.

Hevener KE, Yun MK, Qi J, Kerr ID, Babaoglu K, Hurdle JG, Balakrishna K, White SW, Lee RE. Hevener KE, et al. Among authors: hurdle jg. J Med Chem. 2010 Jan 14;53(1):166-77. doi: 10.1021/jm900861d. J Med Chem. 2010. PMID: 19899766 Free PMC article.

5

Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead.

Sun D, Hurdle JG, Lee R, Lee R, Cushman M, Pezzuto JM. Sun D, et al. Among authors: hurdle jg. ChemMedChem. 2012 Sep;7(9):1541-5. doi: 10.1002/cmdc.201200253. Epub 2012 Jul 30. ChemMedChem. 2012. PMID: 22847956 Free PMC article.

6

The membrane as a target for controlling hypervirulent Clostridium difficile infections.

Wu X, Cherian PT, Lee RE, Hurdle JG. Wu X, et al. Among authors: hurdle jg. J Antimicrob Chemother. 2013 Apr;68(4):806-15. doi: 10.1093/jac/dks493. Epub 2012 Dec 21. J Antimicrob Chemother. 2013. PMID: 23264511 Free PMC article.

7

Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents.

Shen L, Maddox MM, Adhikari S, Bruhn DF, Kumar M, Lee RE, Hurdle JG, Lee RE, Sun D. Shen L, et al. Among authors: hurdle jg. J Antibiot (Tokyo). 2013 Jun;66(6):319-25. doi: 10.1038/ja.2013.21. Epub 2013 Apr 3. J Antibiot (Tokyo). 2013. PMID: 23549356 Free PMC article.

8

Screening for a diamond in the rough.

Wu X, Hurdle JG. Wu X, et al. Among authors: hurdle jg. Chem Biol. 2013 Sep 19;20(9):1091-2. doi: 10.1016/j.chembiol.2013.09.002. Chem Biol. 2013. PMID: 24054182 Free PMC article.

9

Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review.

Tsutsumi LS, Owusu YB, Hurdle JG, Sun D. Tsutsumi LS, et al. Among authors: hurdle jg. Curr Top Med Chem. 2014;14(1):152-75. doi: 10.2174/1568026613666131113154753. Curr Top Med Chem. 2014. PMID: 24236721 Free PMC article. Review.

10

Prospects for flavonoid and related phytochemicals as nature-inspired treatments for Clostridium difficile infection.

Wu X, Alam MZ, Feng L, Tsutsumi LS, Sun D, Hurdle JG. Wu X, et al. Among authors: hurdle jg. J Appl Microbiol. 2014 Jan;116(1):23-31. doi: 10.1111/jam.12344. J Appl Microbiol. 2014. PMID: 24479135 Free PMC article.

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