Wu X - Search Results

1

The Fatty Acid Synthesis Protein Enoyl-ACP Reductase II (FabK) is a Target for Narrow-Spectrum Antibacterials for Clostridium difficile Infection.

Marreddy RKR, Wu X, Sapkota M, Prior AM, Jones JA, Sun D, Hevener KE, Hurdle JG. Marreddy RKR, et al. Among authors: wu x. ACS Infect Dis. 2019 Feb 8;5(2):208-217. doi: 10.1021/acsinfecdis.8b00205. Epub 2018 Dec 13. ACS Infect Dis. 2019. PMID: 30501172 Free PMC article.

2

The Clostridium difficile proline racemase is not essential for early logarithmic growth and infection.

Wu X, Hurdle JG. Wu X, et al. Can J Microbiol. 2014 Apr;60(4):251-4. doi: 10.1139/cjm-2013-0903. Epub 2014 Mar 6. Can J Microbiol. 2014. PMID: 24693984 Free PMC article.

3

The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection.

Sapkota M, Marreddy RKR, Wu X, Kumar M, Hurdle JG. Sapkota M, et al. Among authors: wu x. Anaerobe. 2020 Feb;61:102129. doi: 10.1016/j.anaerobe.2019.102129. Epub 2019 Nov 21. Anaerobe. 2020. PMID: 31760080 Free PMC article.

4

The membrane as a target for controlling hypervirulent Clostridium difficile infections.

Wu X, Cherian PT, Lee RE, Hurdle JG. Wu X, et al. J Antimicrob Chemother. 2013 Apr;68(4):806-15. doi: 10.1093/jac/dks493. Epub 2012 Dec 21. J Antimicrob Chemother. 2013. PMID: 23264511 Free PMC article.

5

Screening for a diamond in the rough.

Wu X, Hurdle JG. Wu X, et al. Chem Biol. 2013 Sep 19;20(9):1091-2. doi: 10.1016/j.chembiol.2013.09.002. Chem Biol. 2013. PMID: 24054182 Free PMC article.

6

Mode of action and bactericidal properties of surotomycin against growing and nongrowing Clostridium difficile.

Alam MZ, Wu X, Mascio C, Chesnel L, Hurdle JG. Alam MZ, et al. Among authors: wu x. Antimicrob Agents Chemother. 2015 Sep;59(9):5165-70. doi: 10.1128/AAC.01087-15. Epub 2015 Jun 8. Antimicrob Agents Chemother. 2015. PMID: 26055381 Free PMC article.

7

Gastrointestinal localization of metronidazole by a lactobacilli-inspired tetramic acid motif improves treatment outcomes in the hamster model of Clostridium difficile infection.

Cherian PT, Wu X, Yang L, Scarborough JS, Singh AP, Alam ZA, Lee RE, Hurdle JG. Cherian PT, et al. Among authors: wu x. J Antimicrob Chemother. 2015 Nov;70(11):3061-9. doi: 10.1093/jac/dkv231. Epub 2015 Aug 18. J Antimicrob Chemother. 2015. PMID: 26286574 Free PMC article.

8

Rifamycin Resistance in Clostridium difficile Is Generally Associated with a Low Fitness Burden.

Dang UT, Zamora I, Hevener KE, Adhikari S, Wu X, Hurdle JG. Dang UT, et al. Among authors: wu x. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5604-7. doi: 10.1128/AAC.01137-16. Print 2016 Sep. Antimicrob Agents Chemother. 2016. PMID: 27381389 Free PMC article.

9

Chromosomal Resistance to Metronidazole in Clostridioides difficile Can Be Mediated by Epistasis between Iron Homeostasis and Oxidoreductases.

Deshpande A, Wu X, Huo W, Palmer KL, Hurdle JG. Deshpande A, et al. Among authors: wu x. Antimicrob Agents Chemother. 2020 Jul 22;64(8):e00415-20. doi: 10.1128/AAC.00415-20. Print 2020 Jul 22. Antimicrob Agents Chemother. 2020. PMID: 32457109 Free PMC article.

10

The Integrity of Heme Is Essential for Reproducible Detection of Metronidazole-Resistant Clostridioides difficile by Agar Dilution Susceptibility Tests.

Wu X, Shen WJ, Deshpande A, Olaitan AO, Palmer KL, Garey KW, Hurdle JG. Wu X, et al. J Clin Microbiol. 2021 Aug 18;59(9):e0058521. doi: 10.1128/JCM.00585-21. Epub 2021 Aug 18. J Clin Microbiol. 2021. PMID: 34132582 Free PMC article.

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