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The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules.
Wang ZF, Ursu A, Childs-Disney JL, Guertler R, Yang WY, Bernat V, Rzuczek SG, Fuerst R, Zhang YJ, Gendron TF, Yildirim I, Dwyer BG, Rice JE, Petrucelli L, Disney MD. Wang ZF, et al. Among authors: ursu a. Cell Chem Biol. 2019 Feb 21;26(2):179-190.e12. doi: 10.1016/j.chembiol.2018.10.018. Epub 2018 Nov 29. Cell Chem Biol. 2019. PMID: 30503283 Free PMC article.
Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models.
Bush JA, Aikawa H, Fuerst R, Li Y, Ursu A, Meyer SM, Benhamou RI, Chen JL, Khan T, Wagner-Griffin S, Van Meter MJ, Tong Y, Olafson H, McKee KK, Childs-Disney JL, Gendron TF, Zhang Y, Coyne AN, Wang ET, Yildirim I, Wang KW, Petrucelli L, Rothstein JD, Disney MD. Bush JA, et al. Among authors: ursu a. Sci Transl Med. 2021 Oct 27;13(617):eabd5991. doi: 10.1126/scitranslmed.abd5991. Epub 2021 Oct 27. Sci Transl Med. 2021. PMID: 34705518 Free PMC article.
Design of small molecules targeting RNA structure from sequence.
Ursu A, Childs-Disney JL, Andrews RJ, O'Leary CA, Meyer SM, Angelbello AJ, Moss WN, Disney MD. Ursu A, et al. Chem Soc Rev. 2020 Oct 19;49(20):7252-7270. doi: 10.1039/d0cs00455c. Chem Soc Rev. 2020. PMID: 32935689 Free PMC article. Review.
Small-molecule phenotypic screening with stem cells.
Ursu A, Schöler HR, Waldmann H. Ursu A, et al. Nat Chem Biol. 2017 May 17;13(6):560-563. doi: 10.1038/nchembio.2383. Nat Chem Biol. 2017. PMID: 28514421 No abstract available.
The Convergence of Stem Cell Technologies and Phenotypic Drug Discovery.
Friese A, Ursu A, Hochheimer A, Schöler HR, Waldmann H, Bruder JM. Friese A, et al. Among authors: ursu a. Cell Chem Biol. 2019 Aug 15;26(8):1050-1066. doi: 10.1016/j.chembiol.2019.05.007. Epub 2019 Jun 20. Cell Chem Biol. 2019. PMID: 31231030 Free article. Review.
52 results