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Efficient Parameter Estimation Enables the Prediction of Drug Response Using a Mechanistic Pan-Cancer Pathway Model.
Fröhlich F, Kessler T, Weindl D, Shadrin A, Schmiester L, Hache H, Muradyan A, Schütte M, Lim JH, Heinig M, Theis FJ, Lehrach H, Wierling C, Lange B, Hasenauer J. Fröhlich F, et al. Among authors: schutte m. Cell Syst. 2018 Dec 26;7(6):567-579.e6. doi: 10.1016/j.cels.2018.10.013. Epub 2018 Nov 28. Cell Syst. 2018. PMID: 30503647 Free article.
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.
Schütte M, Risch T, Abdavi-Azar N, Boehnke K, Schumacher D, Keil M, Yildiriman R, Jandrasits C, Borodina T, Amstislavskiy V, Worth CL, Schweiger C, Liebs S, Lange M, Warnatz HJ, Butcher LM, Barrett JE, Sultan M, Wierling C, Golob-Schwarzl N, Lax S, Uranitsch S, Becker M, Welte Y, Regan JL, Silvestrov M, Kehler I, Fusi A, Kessler T, Herwig R, Landegren U, Wienke D, Nilsson M, Velasco JA, Garin-Chesa P, Reinhard C, Beck S, Schäfer R, Regenbrecht CR, Henderson D, Lange B, Haybaeck J, Keilholz U, Hoffmann J, Lehrach H, Yaspo ML. Schütte M, et al. Nat Commun. 2017 Feb 10;8:14262. doi: 10.1038/ncomms14262. Nat Commun. 2017. PMID: 28186126 Free PMC article.
Support of a molecular tumour board by an evidence-based decision management system for precision oncology.
Lamping M, Benary M, Leyvraz S, Messerschmidt C, Blanc E, Kessler T, Schütte M, Lenze D, Jöhrens K, Burock S, Klinghammer K, Ochsenreither S, Sers C, Schäfer R, Tinhofer I, Beule D, Klauschen F, Yaspo ML, Keilholz U, Rieke DT. Lamping M, et al. Among authors: schutte m. Eur J Cancer. 2020 Mar;127:41-51. doi: 10.1016/j.ejca.2019.12.017. Epub 2020 Jan 23. Eur J Cancer. 2020. PMID: 31982633
Biomarker-driven therapies for metastatic uveal melanoma: A prospective precision oncology feasibility study.
Leyvraz S, Konietschke F, Peuker C, Schütte M, Kessler T, Ochsenreither S, Ditzhaus M, Sprünken ED, Dörpholz G, Lamping M, Rieke DT, Klinghammer K, Burock S, Ulrich C, Poch G, Schäfer R, Klauschen F, Joussen A, Yaspo ML, Keilholz U. Leyvraz S, et al. Among authors: schutte m. Eur J Cancer. 2022 Jul;169:146-155. doi: 10.1016/j.ejca.2022.04.004. Epub 2022 May 12. Eur J Cancer. 2022. PMID: 35569281
Exploring the Impact of Saccharin on Neovascular Age-Related Macular Degeneration: A Comprehensive Study in Patients and Mice.
Künzel SE, Pompös IM, Flesch LTM, Frentzel DP, Knecht VA, Winkler S, Skosyrski S, Rübsam A, Dreher F, Kociok N, Schütte M, Dubrac A, Lange B, Yaspo ML, Lehrach H, Strauß O, Joussen AM, Zeitz O. Künzel SE, et al. Among authors: schutte m. Invest Ophthalmol Vis Sci. 2024 Apr 1;65(4):5. doi: 10.1167/iovs.65.4.5. Invest Ophthalmol Vis Sci. 2024. PMID: 38558091 Free PMC article.
AI-driven discovery of blood xenobiotic biomarkers in neovascular age-related macular degeneration using iterative random forests.
Künzel SE, Frentzel DP, Flesch LTM, Knecht VA, Rübsam A, Dreher F, Schütte M, Dubrac A, Lange B, Yaspo ML, Lehrach H, Joussen AM, Zeitz O. Künzel SE, et al. Among authors: schutte m. Graefes Arch Clin Exp Ophthalmol. 2024 Nov;262(11):3567-3575. doi: 10.1007/s00417-024-06538-2. Epub 2024 Jun 6. Graefes Arch Clin Exp Ophthalmol. 2024. PMID: 38842593 Free PMC article.
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.
Fischer U, Forster M, Rinaldi A, Risch T, Sungalee S, Warnatz HJ, Bornhauser B, Gombert M, Kratsch C, Stütz AM, Sultan M, Tchinda J, Worth CL, Amstislavskiy V, Badarinarayan N, Baruchel A, Bartram T, Basso G, Canpolat C, Cario G, Cavé H, Dakaj D, Delorenzi M, Dobay MP, Eckert C, Ellinghaus E, Eugster S, Frismantas V, Ginzel S, Haas OA, Heidenreich O, Hemmrich-Stanisak G, Hezaveh K, Höll JI, Hornhardt S, Husemann P, Kachroo P, Kratz CP, Te Kronnie G, Marovca B, Niggli F, McHardy AC, Moorman AV, Panzer-Grümayer R, Petersen BS, Raeder B, Ralser M, Rosenstiel P, Schäfer D, Schrappe M, Schreiber S, Schütte M, Stade B, Thiele R, von der Weid N, Vora A, Zaliova M, Zhang L, Zichner T, Zimmermann M, Lehrach H, Borkhardt A, Bourquin JP, Franke A, Korbel JO, Stanulla M, Yaspo ML. Fischer U, et al. Among authors: schutte m. Nat Genet. 2015 Sep;47(9):1020-1029. doi: 10.1038/ng.3362. Epub 2015 Jul 27. Nat Genet. 2015. PMID: 26214592 Free PMC article.
301 results