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Page 1
Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.
Marino JP Jr, Fisher PW, Hofmann GA, Kirkpatrick RB, Janson CA, Johnson RK, Ma C, Mattern M, Meek TD, Ryan MD, Schulz C, Smith WW, Tew DG, Tomazek TA Jr, Veber DF, Xiong WC, Yamamoto Y, Yamashita K, Yang G, Thompson SK. Marino JP Jr, et al. Among authors: hofmann ga. J Med Chem. 2007 Aug 9;50(16):3777-85. doi: 10.1021/jm061182w. Epub 2007 Jul 18. J Med Chem. 2007. PMID: 17636946
Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens.
Diaz E, Machutta CA, Chen S, Jiang Y, Nixon C, Hofmann G, Key D, Sweitzer S, Patel M, Wu Z, Creasy CL, Kruger RG, LaFrance L, Verma SK, Pappalardi MB, Le B, Van Aller GS, McCabe MT, Tummino PJ, Pope AJ, Thrall SH, Schwartz B, Brandt M. Diaz E, et al. Among authors: hofmann g. J Biomol Screen. 2012 Dec;17(10):1279-92. doi: 10.1177/1087057112453765. Epub 2012 Aug 17. J Biomol Screen. 2012. PMID: 22904200
High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome.
Harris PA, Duraiswami C, Fisher DT, Fornwald J, Hoffman SJ, Hofmann G, Jiang M, Lehr R, McCormick PM, Nickels L, Schwartz B, Wu Z, Zhang G, Marquis RW, Bertin J, Gough PJ. Harris PA, et al. Among authors: hofmann g. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2739-43. doi: 10.1016/j.bmcl.2015.05.032. Epub 2015 May 19. Bioorg Med Chem Lett. 2015. PMID: 26022841
4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo.
Kallander LS, Lu Q, Chen W, Tomaszek T, Yang G, Tew D, Meek TD, Hofmann GA, Schulz-Pritchard CK, Smith WW, Janson CA, Ryan MD, Zhang GF, Johanson KO, Kirkpatrick RB, Ho TF, Fisher PW, Mattern MR, Johnson RK, Hansbury MJ, Winkler JD, Ward KW, Veber DF, Thompson SK. Kallander LS, et al. Among authors: hofmann ga. J Med Chem. 2005 Sep 8;48(18):5644-7. doi: 10.1021/jm050408c. J Med Chem. 2005. PMID: 16134930
Identification of novel isoform-selective inhibitors within class I histone deacetylases.
Hu E, Dul E, Sung CM, Chen Z, Kirkpatrick R, Zhang GF, Johanson K, Liu R, Lago A, Hofmann G, Macarron R, de los Frailes M, Perez P, Krawiec J, Winkler J, Jaye M. Hu E, et al. Among authors: hofmann g. J Pharmacol Exp Ther. 2003 Nov;307(2):720-8. doi: 10.1124/jpet.103.055541. Epub 2003 Sep 15. J Pharmacol Exp Ther. 2003. PMID: 12975486
Topoisomerase II in multiple drug resistance.
Hofmann GA, Mattern MR. Hofmann GA, et al. Cytotechnology. 1993;12(1-3):137-54. doi: 10.1007/BF00744662. Cytotechnology. 1993. PMID: 7765323 Review.
3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
Tedesco R, Shaw AN, Bambal R, Chai D, Concha NO, Darcy MG, Dhanak D, Fitch DM, Gates A, Gerhardt WG, Halegoua DL, Han C, Hofmann GA, Johnston VK, Kaura AC, Liu N, Keenan RM, Lin-Goerke J, Sarisky RT, Wiggall KJ, Zimmerman MN, Duffy KJ. Tedesco R, et al. Among authors: hofmann ga. J Med Chem. 2006 Feb 9;49(3):971-83. doi: 10.1021/jm050855s. J Med Chem. 2006. PMID: 16451063
875 results