Chen CL - Search Results

1

Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization.

Hasan SS, Sun C, Kim AS, Watanabe Y, Chen CL, Klose T, Buda G, Crispin M, Diamond MS, Klimstra WB, Rossmann MG. Hasan SS, et al. Among authors: chen cl. Cell Rep. 2018 Dec 11;25(11):3136-3147.e5. doi: 10.1016/j.celrep.2018.11.067. Cell Rep. 2018. PMID: 30540945 Free PMC article.

2

Cryo-EM structure of eastern equine encephalitis virus in complex with heparan sulfate analogues.

Chen CL, Hasan SS, Klose T, Sun Y, Buda G, Sun C, Klimstra WB, Rossmann MG. Chen CL, et al. Proc Natl Acad Sci U S A. 2020 Apr 21;117(16):8890-8899. doi: 10.1073/pnas.1910670117. Epub 2020 Apr 3. Proc Natl Acad Sci U S A. 2020. PMID: 32245806 Free PMC article.

3

Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.

Chen Q, Plasencia M, Li Z, Mukherjee S, Patra D, Chen CL, Klose T, Yao XQ, Kossiakoff AA, Chang L, Andrews PC, Tesmer JJG. Chen Q, et al. Among authors: chen cl. Nature. 2021 Jul;595(7868):600-605. doi: 10.1038/s41586-021-03721-x. Epub 2021 Jul 14. Nature. 2021. PMID: 34262173 Free PMC article.

4

Cryo-EM structures of alphavirus conformational intermediates in low pH-triggered prefusion states.

Chen CL, Klose T, Sun C, Kim AS, Buda G, Rossmann MG, Diamond MS, Klimstra WB, Kuhn RJ. Chen CL, et al. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2114119119. doi: 10.1073/pnas.2114119119. Epub 2022 Jul 22. Proc Natl Acad Sci U S A. 2022. PMID: 35867819 Free PMC article.

5

Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ.

Chen CL, Syahirah R, Ravala SK, Yen YC, Klose T, Deng Q, Tesmer JJG. Chen CL, et al. bioRxiv [Preprint]. 2023 May 5:2023.05.04.539492. doi: 10.1101/2023.05.04.539492. bioRxiv. 2023. Update in: Nat Struct Mol Biol. 2024 Aug;31(8):1198-1207. doi: 10.1038/s41594-024-01265-y PMID: 37205329 Free PMC article. Updated. Preprint.

6

Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ.

Yen YC, Li Y, Chen CL, Klose T, Watts VJ, Dessauer CW, Tesmer JJG. Yen YC, et al. Among authors: chen cl. bioRxiv [Preprint]. 2023 May 2:2023.05.02.539090. doi: 10.1101/2023.05.02.539090. bioRxiv. 2023. PMID: 37205557 Free PMC article. Preprint.

7

Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ.

Chen CL, Syahirah R, Ravala SK, Yen YC, Klose T, Deng Q, Tesmer JJG. Chen CL, et al. Nat Struct Mol Biol. 2024 Aug;31(8):1198-1207. doi: 10.1038/s41594-024-01265-y. Epub 2024 Apr 2. Nat Struct Mol Biol. 2024. PMID: 38565696

8

Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia.

Yen YC, Li Y, Chen CL, Klose T, Watts VJ, Dessauer CW, Tesmer JJG. Yen YC, et al. Among authors: chen cl. Nat Struct Mol Biol. 2024 Aug;31(8):1189-1197. doi: 10.1038/s41594-024-01263-0. Epub 2024 Apr 8. Nat Struct Mol Biol. 2024. PMID: 38589608

9

Structural and dynamic changes in P-Rex1 upon activation by PIP₃ and inhibition by IP₄.

Ravala SK, Adame-Garcia SR, Li S, Chen CL, Cianfrocco MA, Silvio Gutkind J, Cash JN, Tesmer JJG. Ravala SK, et al. Among authors: chen cl. Elife. 2024 Jul 31;12:RP92822. doi: 10.7554/eLife.92822. Elife. 2024. PMID: 39082940 Free PMC article.

10

Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1.

Bandekar SJ, Chen CL, Ravala SK, Cash JN, Avramova LV, Zhalnina MV, Gutkind JS, Li S, Tesmer JJG. Bandekar SJ, et al. Among authors: chen cl. J Biol Chem. 2022 Aug;298(8):102209. doi: 10.1016/j.jbc.2022.102209. Epub 2022 Jun 30. J Biol Chem. 2022. PMID: 35779635 Free PMC article.

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