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Page 1
A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium.
Boulay E, Abernathy MM, Chui R, Friedrichs GS, Gendron-Parra N, Greiter-Wilke A, Guillon JM, Koerner JE, Menard A, Steidl-Nichols J, Pierson J, Pugsley MK, Rossman EI, Strauss D, Troncy E, Valentin JP, Wisialowski T, Authier S. Boulay E, et al. Among authors: abernathy mm. Int J Toxicol. 2019 Jan/Feb;38(1):23-32. doi: 10.1177/1091581818813601. Epub 2018 Dec 19. Int J Toxicol. 2019. PMID: 30567462
An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation.
Authier S, Abernathy MM, Correll K, Chui RW, Dalton J, Foley CM, Friedrichs GS, Koerner JE, Kallman MJ, Pannirselvam M, Redfern WS, Urmaliya V, Valentin JP, Wisialowski T, Zabka TS, Pugsley MK. Authier S, et al. Among authors: abernathy mm. Int J Toxicol. 2020 Jul/Aug;39(4):274-293. doi: 10.1177/1091581820921338. Epub 2020 May 14. Int J Toxicol. 2020. PMID: 32406289
Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off-label in the first wave of COVID-19.
Delaunois A, Abernathy M, Anderson WD, Beattie KA, Chaudhary KW, Coulot J, Gryshkova V, Hebeisen S, Holbrook M, Kramer J, Kuryshev Y, Leishman D, Lushbough I, Passini E, Redfern WS, Rodriguez B, Rossman EI, Trovato C, Wu C, Valentin JP. Delaunois A, et al. Clin Transl Sci. 2021 May;14(3):1133-1146. doi: 10.1111/cts.13011. Epub 2021 Apr 9. Clin Transl Sci. 2021. PMID: 33620150 Free PMC article.
The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis.
Boulay E, Miraucourt LS, Pugsley MK, Abernathy MM, Chui R, Dalton J, Demers M, Dybdal N, Gazaille E, Greiter-Wilke A, Hoffmann P, Huang H, LaDuke C, Norton K, Pierson JB, Reeves I, Roche B, Rossman EI, Schultze AE, Tang HM, Wisialowski T, Authier S. Boulay E, et al. Among authors: abernathy mm. J Pharmacol Toxicol Methods. 2023 May-Jun;121:107266. doi: 10.1016/j.vascn.2023.107266. Epub 2023 Mar 22. J Pharmacol Toxicol Methods. 2023. PMID: 36963703 Free article.
Reevaluating safety pharmacology respiratory studies within the ICH S7A core battery: A multi-company evaluation of preclinical utility and clinical translation.
Friedrichs GS, Abernathy MM, Ackley D, Clark M, DaSilva JK, Foley CM, Greiter-Wilke A, Henderson KA, Kremer JJ, Morimoto BH, Paglialunga S, Pugsley MK, Regan CP, Rossman EI, Segretti JA, Traebert M, Vargas HM, Wisialowski TA. Friedrichs GS, et al. Among authors: abernathy mm. Regul Toxicol Pharmacol. 2024 Nov;153:105706. doi: 10.1016/j.yrtph.2024.105706. Epub 2024 Sep 16. Regul Toxicol Pharmacol. 2024. PMID: 39293707
Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective.
Reynolds VL, Butler P, Abernathy MM, Aschenbrenner L, Best DD, Blank J, Crosby M, Custer L, Escobar PA, Kolaja K, Moggs J, Shuey D, Snyder C, Van Vleet T, Zhou J, Hart TK. Reynolds VL, et al. Among authors: abernathy mm. Regul Toxicol Pharmacol. 2020 Nov;117:104746. doi: 10.1016/j.yrtph.2020.104746. Epub 2020 Sep 8. Regul Toxicol Pharmacol. 2020. PMID: 32911461
The Safety Pharmacology of Auditory Function.
Abernathy MM. Abernathy MM. Handb Exp Pharmacol. 2015;229:267-90. doi: 10.1007/978-3-662-46943-9_11. Handb Exp Pharmacol. 2015. PMID: 26091644 Review.
17 results