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Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease.
Cansby E, Nuñez-Durán E, Magnusson E, Amrutkar M, Booten SL, Kulkarni NM, Svensson LT, Borén J, Marschall HU, Aghajan M, Mahlapuu M. Cansby E, et al. Among authors: boren j. Cell Mol Gastroenterol Hepatol. 2019;7(3):597-618. doi: 10.1016/j.jcmgh.2018.12.004. Epub 2018 Dec 19. Cell Mol Gastroenterol Hepatol. 2019. PMID: 30576769 Free PMC article.
Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro.
Pirazzi C, Adiels M, Burza MA, Mancina RM, Levin M, Ståhlman M, Taskinen MR, Orho-Melander M, Perman J, Pujia A, Andersson L, Maglio C, Montalcini T, Wiklund O, Borén J, Romeo S. Pirazzi C, et al. Among authors: boren j. J Hepatol. 2012 Dec;57(6):1276-82. doi: 10.1016/j.jhep.2012.07.030. Epub 2012 Aug 6. J Hepatol. 2012. PMID: 22878467
STK25 is a critical determinant in nonalcoholic steatohepatitis.
Amrutkar M, Chursa U, Kern M, Nuñez-Durán E, Ståhlman M, Sütt S, Borén J, Johansson BR, Marschall HU, Blüher M, Mahlapuu M. Amrutkar M, et al. Among authors: boren j. FASEB J. 2016 Oct;30(10):3628-3643. doi: 10.1096/fj.201600562R. Epub 2016 Jul 15. FASEB J. 2016. PMID: 27421788
-Amrutkar, M., Chursa, U., Kern, M., Nunez-Duran, E., Stahlman, M., Sutt, S., Boren, J., Johansson, B. R., Marschall, H.-U., Bluher, M., Mahlapuu, M. STK25 is a critical determinant in nonalcoholic steatohepatitis....
-Amrutkar, M., Chursa, U., Kern, M., Nunez-Duran, E., Stahlman, M., Sutt, S., Boren, J., Johansson, B. R., Marschall, H.-U., B …
Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle.
Chursa U, Nuñez-Durán E, Cansby E, Amrutkar M, Sütt S, Ståhlman M, Olsson BM, Borén J, Johansson ME, Bäckhed F, Johansson BR, Sihlbom C, Mahlapuu M. Chursa U, et al. Among authors: boren j. Diabetologia. 2017 Mar;60(3):553-567. doi: 10.1007/s00125-016-4171-5. Epub 2016 Dec 16. Diabetologia. 2017. PMID: 27981357 Free PMC article.
Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD.
Mardinoglu A, Bjornson E, Zhang C, Klevstig M, Söderlund S, Ståhlman M, Adiels M, Hakkarainen A, Lundbom N, Kilicarslan M, Hallström BM, Lundbom J, Vergès B, Barrett PH, Watts GF, Serlie MJ, Nielsen J, Uhlén M, Smith U, Marschall HU, Taskinen MR, Boren J. Mardinoglu A, et al. Among authors: boren j. Mol Syst Biol. 2017 Mar 2;13(3):916. doi: 10.15252/msb.20167422. Mol Syst Biol. 2017. PMID: 28254760 Free PMC article.
493 results