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Dynamic conformational equilibria in the active states of KRAS and NRAS.
Rennella E, Henry C, Dickson CJ, Georgescauld F, Wales TE, Erdmann D, Cotesta S, Maira M, Sedrani R, Brachmann SM, Ostermann N, Engen JR, Kay LE, Beyer KS, Wilcken R, Jahnke W. Rennella E, et al. Among authors: wales te. RSC Chem Biol. 2024 Nov 25;6(1):106-118. doi: 10.1039/d4cb00233d. eCollection 2025 Jan 2. RSC Chem Biol. 2024. PMID: 39664928 Free PMC article.
Covalent inhibition of pro-apoptotic BAX.
McHenry MW, Shi P, Camara CM, Cohen DT, Rettenmaier TJ, Adhikary U, Gygi MA, Yang K, Gygi SP, Wales TE, Engen JR, Wells JA, Walensky LD. McHenry MW, et al. Among authors: wales te. Nat Chem Biol. 2024 Aug;20(8):1022-1032. doi: 10.1038/s41589-023-01537-6. Epub 2024 Jan 17. Nat Chem Biol. 2024. PMID: 38233584
Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.
Joseph RE, Wales TE, Jayne S, Britton RG, Fulton DB, Engen JR, Dyer MJS, Andreotti AH. Joseph RE, et al. Among authors: wales te. bioRxiv [Preprint]. 2024 Oct 10:2023.12.18.572223. doi: 10.1101/2023.12.18.572223. bioRxiv. 2024. Update in: Elife. 2024 Dec 27;13:RP95488. doi: 10.7554/eLife.95488 PMID: 38187560 Free PMC article. Updated. Preprint.
94 results