Pati ML - Search Results

1

Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability.

Pati ML, Vitale P, Ferorelli S, Iaselli M, Miciaccia M, Boccarelli A, Di Mauro GD, Fortuna CG, Souza Domingos TF, Rodrigues Pereira da Silva LC, de Pádula M, Cabral LM, Sathler PC, Vacca A, Scilimati A, Perrone MG. Pati ML, et al. Eur J Med Chem. 2019 Feb 15;164:59-76. doi: 10.1016/j.ejmech.2018.12.029. Epub 2018 Dec 15. Eur J Med Chem. 2019. PMID: 30590258

2

Targeting COX-1 by mofezolac-based fluorescent probes for ovarian cancer detection.

Scilimati A, Ferorelli S, Iaselli MC, Miciaccia M, Pati ML, Fortuna CG, Aleem AM, Marnett LJ, Perrone MG. Scilimati A, et al. Among authors: pati ml. Eur J Med Chem. 2019 Oct 1;179:16-25. doi: 10.1016/j.ejmech.2019.06.039. Epub 2019 Jun 15. Eur J Med Chem. 2019. PMID: 31229884

3

Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents.

Pati ML, Abate C, Contino M, Ferorelli S, Luisi R, Carroccia L, Niso M, Berardi F. Pati ML, et al. Eur J Med Chem. 2015 Jan 7;89:691-700. doi: 10.1016/j.ejmech.2014.11.001. Epub 2014 Nov 4. Eur J Med Chem. 2015. PMID: 25462276

4

From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump.

Abate C, Pati ML, Contino M, Colabufo NA, Perrone R, Niso M, Berardi F. Abate C, et al. Among authors: pati ml. Eur J Med Chem. 2015 Jan 7;89:606-15. doi: 10.1016/j.ejmech.2014.10.082. Epub 2014 Oct 30. Eur J Med Chem. 2015. PMID: 25462269

5

Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (σ₂) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors.

Pati ML, Niso M, Spitzer D, Berardi F, Contino M, Riganti C, Hawkins WG, Abate C. Pati ML, et al. Eur J Med Chem. 2018 Jan 20;144:359-371. doi: 10.1016/j.ejmech.2017.12.024. Epub 2017 Dec 8. Eur J Med Chem. 2018. PMID: 29287249 Free PMC article.

6

Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors.

Abate C, Riganti C, Pati ML, Ghigo D, Berardi F, Mavlyutov T, Guo LW, Ruoho A. Abate C, et al. Among authors: pati ml. Eur J Med Chem. 2016 Jan 27;108:577-585. doi: 10.1016/j.ejmech.2015.12.014. Epub 2015 Dec 13. Eur J Med Chem. 2016. PMID: 26717207 Free PMC article.

7

Novel and Selective Fluorescent σ2 -Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells.

Niso M, Riganti C, Pati ML, Ghigo D, Berardi F, Abate C. Niso M, et al. Among authors: pati ml. Chembiochem. 2015 May 4;16(7):1078-83. doi: 10.1002/cbic.201402712. Epub 2015 Mar 10. Chembiochem. 2015. PMID: 25757101

8

Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer.

Pati ML, Hornick JR, Niso M, Berardi F, Spitzer D, Abate C, Hawkins W. Pati ML, et al. BMC Cancer. 2017 Jan 13;17(1):51. doi: 10.1186/s12885-016-3040-4. BMC Cancer. 2017. PMID: 28086830 Free PMC article.

9

Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1.

Pati ML, Groza D, Riganti C, Kopecka J, Niso M, Berardi F, Hager S, Heffeter P, Hirai M, Tsugawa H, Kabe Y, Suematsu M, Abate C. Pati ML, et al. Pharmacol Res. 2017 Mar;117:67-74. doi: 10.1016/j.phrs.2016.12.023. Epub 2016 Dec 19. Pharmacol Res. 2017. PMID: 28007569

10

Synthesis, radiolabelling, and evaluation of [¹¹C]PB212 as a radioligand for imaging sigma-1 receptors using PET.

Spinelli F, Haider A, Toscano A, Pati ML, Keller C, Berardi F, Colabufo NA, Abate C, Ametamey SM. Spinelli F, et al. Among authors: pati ml. Am J Nucl Med Mol Imaging. 2018 Feb 5;8(1):32-40. eCollection 2018. Am J Nucl Med Mol Imaging. 2018. PMID: 29531859 Free PMC article.

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