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Page 1
Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.
Granberg KL, Yuan ZQ, Lindmark B, Edman K, Kajanus J, Hogner A, Malmgren M, O'Mahony G, Nordqvist A, Lindberg J, Tångefjord S, Kossenjans M, Löfberg C, Brånalt J, Liu D, Selmi N, Nikitidis G, Nordberg P, Hayen A, Aagaard A, Hansson E, Hermansson M, Ivarsson I, Jansson-Löfmark R, Karlsson U, Johansson U, William-Olsson L, Hartleib-Geschwindner J, Bamberg K. Granberg KL, et al. J Med Chem. 2019 Feb 14;62(3):1385-1406. doi: 10.1021/acs.jmedchem.8b01523. Epub 2019 Jan 30. J Med Chem. 2019. PMID: 30596500
Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.
Bamberg K, Johansson U, Edman K, William-Olsson L, Myhre S, Gunnarsson A, Geschwindner S, Aagaard A, Björnson Granqvist A, Jaisser F, Huang Y, Granberg KL, Jansson-Löfmark R, Hartleib-Geschwindner J. Bamberg K, et al. PLoS One. 2018 Feb 23;13(2):e0193380. doi: 10.1371/journal.pone.0193380. eCollection 2018. PLoS One. 2018. PMID: 29474466 Free PMC article.
Clinical safety, tolerability, pharmacokinetics and effects on urinary electrolyte excretion of AZD9977, a novel, selective mineralocorticoid receptor modulator.
Erlandsson F, Albayaty M, Chialda L, Ericsson H, Amilon C, Nelander K, Jansson-Löfmark R, Wernevik L, Kjaer M, Bamberg K, Hartleib-Geschwindner J. Erlandsson F, et al. Br J Clin Pharmacol. 2018 Jul;84(7):1486-1493. doi: 10.1111/bcp.13562. Epub 2018 Apr 22. Br J Clin Pharmacol. 2018. PMID: 29468715 Free PMC article. Clinical Trial.
A case-study of model-informed drug development of a novel PCSK9 anti sense oligonucleotide. Part 1: First time in man to phase II.
Knöchel J, Nilsson C, Carlsson B, Wernevik L, Hofherr A, Gennemark P, Jansson-Löfmark R, Isaksson R, Rydén-Bergsten T, Hamrén B, Rekić D. Knöchel J, et al. Among authors: jansson lofmark r. CPT Pharmacometrics Syst Pharmacol. 2022 Dec;11(12):1569-1577. doi: 10.1002/psp4.12866. Epub 2022 Oct 1. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 36126230 Free PMC article. Clinical Trial.
Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity.
Kvitne KE, Krogstad V, Wegler C, Johnson LK, Kringen MK, Hovd MH, Hertel JK, Heijer M, Sandbu R, Skovlund E, Artursson P, Karlsson C, Andersson S, Andersson TB, Hjelmesaeth J, Åsberg A, Jansson-Löfmark R, Christensen H, Robertsen I. Kvitne KE, et al. Br J Clin Pharmacol. 2022 Sep;88(9):4121-4133. doi: 10.1111/bcp.15349. Epub 2022 Apr 25. Br J Clin Pharmacol. 2022. PMID: 35404513 Free PMC article. Clinical Trial.
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