Wang J - Search Results

1

Discovery of a new class of valosine containing protein (VCP/P97) inhibitors for the treatment of non-small cell lung cancer.

Wang X, Bai E, Zhou H, Sha S, Miao H, Qin Y, Liu Z, Wang J, Zhang H, Lei M, Liu J, Hai O, Zhu Y. Wang X, et al. Among authors: wang j. Bioorg Med Chem. 2019 Feb 1;27(3):533-544. doi: 10.1016/j.bmc.2018.12.036. Epub 2018 Dec 28. Bioorg Med Chem. 2019. PMID: 30606672

2

Design, synthesis and docking studies of novel dipeptidyl boronic acid proteasome inhibitors constructed from αα- and αβ-amino acids.

Shi J, Lei M, Wu W, Feng H, Wang J, Chen S, Zhu Y, Hu S, Liu Z, Jiang C. Shi J, et al. Among authors: wang j. Bioorg Med Chem Lett. 2016 Apr 15;26(8):1958-62. doi: 10.1016/j.bmcl.2016.03.007. Epub 2016 Mar 3. Bioorg Med Chem Lett. 2016. PMID: 26965867

3

3D-QSAR-aided design, synthesis, in vitro and in vivo evaluation of dipeptidyl boronic acid proteasome inhibitors and mechanism studies.

Lei M, Feng H, Wang C, Li H, Shi J, Wang J, Liu Z, Chen S, Hu S, Zhu Y. Lei M, et al. Among authors: wang j, wang c. Bioorg Med Chem. 2016 Jun 1;24(11):2576-2588. doi: 10.1016/j.bmc.2016.04.025. Epub 2016 Apr 13. Bioorg Med Chem. 2016. PMID: 27117691

4

Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.

Zhang H, Wu W, Feng C, Liu Z, Bai E, Wang X, Lei M, Cheng H, Feng H, Shi J, Wang J, Zhang Z, Jin T, Chen S, Hu S, Zhu Y. Zhang H, et al. Among authors: wang x, wang j. Eur J Med Chem. 2017 Jul 28;135:12-23. doi: 10.1016/j.ejmech.2017.04.036. Epub 2017 Apr 14. Eur J Med Chem. 2017. PMID: 28426996

5

Design, synthesis, in vitro and in vivo evaluation, and structure-activity relationship (SAR) discussion of novel dipeptidyl boronic acid proteasome inhibitors as orally available anti-cancer agents for the treatment of multiple myeloma and mechanism studies.

Lei M, Feng H, Bai E, Zhou H, Wang J, Shi J, Wang X, Hu S, Liu Z, Zhu Y. Lei M, et al. Among authors: wang x, wang j. Bioorg Med Chem. 2018 Aug 7;26(14):3975-3981. doi: 10.1016/j.bmc.2018.06.020. Epub 2018 Jun 18. Bioorg Med Chem. 2018. PMID: 29934218

6

Discovery of a novel dipeptidyl boronic acid proteasome inhibitor for the treatment of multiple myeloma and triple-negative breast cancer.

Lei M, Feng H, Bai E, Zhou H, Wang J, Qin Y, Zhang H, Wang X, Liu Z, Hai O, Liu J, Zhu Y. Lei M, et al. Among authors: wang x, wang j. Org Biomol Chem. 2019 Jan 16;17(3):683-691. doi: 10.1039/c8ob02668h. Org Biomol Chem. 2019. PMID: 30601533

7

Preparation and biological evaluation of soluble tetrapeptide epoxyketone proteasome inhibitors.

Lei M, Zhang H, Miao H, Du X, Zhou H, Wang J, Wang X, Feng H, Shi J, Liu Z, Shen J, Zhu Y. Lei M, et al. Among authors: wang x, wang j. Bioorg Med Chem. 2019 Sep 15;27(18):4151-4162. doi: 10.1016/j.bmc.2019.07.044. Epub 2019 Jul 30. Bioorg Med Chem. 2019. PMID: 31383629

8

Discovery of novel tripeptide propylene oxide proteasome inhibitors for the treatment of multiple myeloma.

Zhang W, Wang X, Zhang H, Wen T, Yang L, Miao H, Wang J, Liu H, Yang X, Lei M, Zhu Y. Zhang W, et al. Among authors: wang x, wang j. Bioorg Med Chem. 2021 Jun 15;40:116182. doi: 10.1016/j.bmc.2021.116182. Epub 2021 May 1. Bioorg Med Chem. 2021. PMID: 33971487

9

Design, Synthesis and Biological Evaluation of the Quinazoline Derivatives as L858R/T790M/C797S Triple Mutant Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors.

Zhang M, Wang Y, Wang J, Liu Z, Shi J, Li M, Zhu Y, Wang S. Zhang M, et al. Among authors: wang j, wang y, wang s. Chem Pharm Bull (Tokyo). 2020;68(10):971-980. doi: 10.1248/cpb.c20-00411. Chem Pharm Bull (Tokyo). 2020. PMID: 32999149 Free article.

10

In vitro and in vivo efficacy of the novel oral proteasome inhibitor NNU546 in multiple myeloma.

Zhou H, Lei M, Wang W, Guo M, Wang J, Zhang H, Qiao L, Feng H, Liu Z, Chen L, Hou J, Wang X, Gu C, Zhao B, Izumchenko E, Yang Y, Zhu Y. Zhou H, et al. Among authors: wang x, wang w, wang j. Aging (Albany NY). 2020 Nov 16;12(22):22949-22974. doi: 10.18632/aging.104023. Epub 2020 Nov 16. Aging (Albany NY). 2020. PMID: 33203800 Free PMC article.

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