Yan H - Search Results

1

Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction.

Karwi QG, Zhang L, Wagg CS, Wang W, Ghandi M, Thai D, Yan H, Ussher JR, Oudit GY, Lopaschuk GD. Karwi QG, et al. Among authors: yan h. Cardiovasc Diabetol. 2019 Jan 9;18(1):1. doi: 10.1186/s12933-019-0806-4. Cardiovasc Diabetol. 2019. PMID: 30626440 Free PMC article.

2

Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway.

Wang MY, Yan H, Shi Z, Evans MR, Yu X, Lee Y, Chen S, Williams A, Philippe J, Roth MG, Unger RH. Wang MY, et al. Among authors: yan h. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2503-8. doi: 10.1073/pnas.1424934112. Epub 2015 Feb 9. Proc Natl Acad Sci U S A. 2015. PMID: 25675519 Free PMC article.

3

Insulin and Glucagon: Partners for Life.

Holst JJ, Holland W, Gromada J, Lee Y, Unger RH, Yan H, Sloop KW, Kieffer TJ, Damond N, Herrera PL. Holst JJ, et al. Among authors: yan h. Endocrinology. 2017 Apr 1;158(4):696-701. doi: 10.1210/en.2016-1748. Endocrinology. 2017. PMID: 28323959 Free PMC article. Review.

4

Effect of a glucagon receptor antibody (REMD-477) in type 1 diabetes: A randomized controlled trial.

Pettus J, Reeds D, Cavaiola TS, Boeder S, Levin M, Tobin G, Cava E, Thai D, Shi J, Yan H, Bautista E, McMillan J, Unger R, Henry RR, Klein S. Pettus J, et al. Among authors: yan h. Diabetes Obes Metab. 2018 May;20(5):1302-1305. doi: 10.1111/dom.13202. Epub 2018 Jan 22. Diabetes Obes Metab. 2018. PMID: 29283470 Free PMC article. Clinical Trial.

5

Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice.

Sharma AX, Quittner-Strom EB, Lee Y, Johnson JA, Martin SA, Yu X, Li J, Lu J, Cai Z, Chen S, Wang MY, Zhang Y, Pearson MJ, Dorn AC, McDonald JG, Gordillo R, Yan H, Thai D, Wang ZV, Unger RH, Holland WL. Sharma AX, et al. Among authors: yan h. Cell Rep. 2018 Feb 13;22(7):1760-1773. doi: 10.1016/j.celrep.2018.01.065. Cell Rep. 2018. PMID: 29444429 Free PMC article.

6

Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure.

Gao C, Ren SV, Yu J, Baal U, Thai D, Lu J, Zeng C, Yan H, Wang Y. Gao C, et al. Among authors: yan h. JACC Basic Transl Sci. 2019 Mar 13;4(2):161-172. doi: 10.1016/j.jacbts.2018.11.001. eCollection 2019 Apr. JACC Basic Transl Sci. 2019. PMID: 31061918 Free PMC article.

7

Antagonistic Glucagon Receptor Antibody Promotes α-Cell Proliferation and Increases β-Cell Mass in Diabetic Mice.

Wei R, Gu L, Yang J, Yang K, Liu J, Le Y, Lang S, Wang H, Thai D, Yan H, Hong T. Wei R, et al. Among authors: yan h. iScience. 2019 Jun 28;16:326-339. doi: 10.1016/j.isci.2019.05.030. Epub 2019 May 30. iScience. 2019. PMID: 31203188 Free PMC article.

8

Glucagon receptor antagonism promotes the production of gut proglucagon-derived peptides in diabetic mice.

Lang S, Wei R, Wei T, Gu L, Feng J, Yan H, Yang J, Hong T. Lang S, et al. Among authors: yan h. Peptides. 2020 Sep;131:170349. doi: 10.1016/j.peptides.2020.170349. Epub 2020 Jun 16. Peptides. 2020. PMID: 32561493

9

Targeting the glucagon receptor signaling pathway as a novel strategy to counteract PI3K inhibitor induced hyperglycemia while sustaining tumor PI3K inhibition.

Wang J, Osada T, Morse MA, Calzone F, Yan H, Thai D, Lyerly HK. Wang J, et al. Among authors: yan h. Leuk Lymphoma. 2021 Jul;62(7):1761-1764. doi: 10.1080/10428194.2021.1881504. Epub 2021 Feb 12. Leuk Lymphoma. 2021. PMID: 33576297 Free article. No abstract available.

10

Glucagon receptor antagonist volagidemab in type 1 diabetes: a 12-week, randomized, double-blind, phase 2 trial.

Pettus J, Boeder SC, Christiansen MP, Denham DS, Bailey TS, Akturk HK, Klaff LJ, Rosenstock J, Cheng MHM, Bode BW, Bautista ED, Xu R, Yan H, Thai D, Garg SK, Klein S. Pettus J, et al. Among authors: yan h. Nat Med. 2022 Oct;28(10):2092-2099. doi: 10.1038/s41591-022-02011-x. Epub 2022 Oct 3. Nat Med. 2022. PMID: 36192552 Free PMC article. Clinical Trial.

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