Tonelli F - Search Results

1

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

Purlyte E, Dhekne HS, Sarhan AR, Gomez R, Lis P, Wightman M, Martinez TN, Tonelli F, Pfeffer SR, Alessi DR. Purlyte E, et al. Among authors: tonelli f. EMBO J. 2019 Jan 15;38(2):e101237. doi: 10.15252/embj.2018101237. EMBO J. 2019. PMID: 30647193 Free PMC article.

2

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

Steger M, Tonelli F, Ito G, Davies P, Trost M, Vetter M, Wachter S, Lorentzen E, Duddy G, Wilson S, Baptista MA, Fiske BK, Fell MJ, Morrow JA, Reith AD, Alessi DR, Mann M. Steger M, et al. Among authors: tonelli f. Elife. 2016 Jan 29;5:e12813. doi: 10.7554/eLife.12813. Elife. 2016. PMID: 26824392 Free PMC article.

3

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.

Ito G, Katsemonova K, Tonelli F, Lis P, Baptista MA, Shpiro N, Duddy G, Wilson S, Ho PW, Ho SL, Reith AD, Alessi DR. Ito G, et al. Among authors: tonelli f. Biochem J. 2016 Sep 1;473(17):2671-85. doi: 10.1042/BCJ20160557. Epub 2016 Jul 29. Biochem J. 2016. PMID: 27474410 Free PMC article.

4

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

Steger M, Diez F, Dhekne HS, Lis P, Nirujogi RS, Karayel O, Tonelli F, Martinez TN, Lorentzen E, Pfeffer SR, Alessi DR, Mann M. Steger M, et al. Among authors: tonelli f. Elife. 2017 Nov 10;6:e31012. doi: 10.7554/eLife.31012. Elife. 2017. PMID: 29125462 Free PMC article.

5

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase.

Lis P, Burel S, Steger M, Mann M, Brown F, Diez F, Tonelli F, Holton JL, Ho PW, Ho SL, Chou MY, Polinski NK, Martinez TN, Davies P, Alessi DR. Lis P, et al. Among authors: tonelli f. Biochem J. 2018 Jan 2;475(1):1-22. doi: 10.1042/BCJ20170802. Biochem J. 2018. PMID: 29127256 Free PMC article.

6

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

Purlyte E, Dhekne HS, Sarhan AR, Gomez R, Lis P, Wightman M, Martinez TN, Tonelli F, Pfeffer SR, Alessi DR. Purlyte E, et al. Among authors: tonelli f. EMBO J. 2018 Jan 4;37(1):1-18. doi: 10.15252/embj.201798099. Epub 2017 Dec 6. EMBO J. 2018. PMID: 29212815 Free PMC article.

7

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.

Mir R, Tonelli F, Lis P, Macartney T, Polinski NK, Martinez TN, Chou MY, Howden AJM, König T, Hotzy C, Milenkovic I, Brücke T, Zimprich A, Sammler E, Alessi DR. Mir R, et al. Among authors: tonelli f. Biochem J. 2018 Jun 6;475(11):1861-1883. doi: 10.1042/BCJ20180248. Biochem J. 2018. PMID: 29743203 Free PMC article.

8

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.

Dhekne HS, Yanatori I, Gomez RC, Tonelli F, Diez F, Schüle B, Steger M, Alessi DR, Pfeffer SR. Dhekne HS, et al. Among authors: tonelli f. Elife. 2018 Nov 6;7:e40202. doi: 10.7554/eLife.40202. Elife. 2018. PMID: 30398148 Free PMC article.

9

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins.

Berndsen K, Lis P, Yeshaw WM, Wawro PS, Nirujogi RS, Wightman M, Macartney T, Dorward M, Knebel A, Tonelli F, Pfeffer SR, Alessi DR. Berndsen K, et al. Among authors: tonelli f. Elife. 2019 Oct 30;8:e50416. doi: 10.7554/eLife.50416. Elife. 2019. PMID: 31663853 Free PMC article.

10

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation.

Fan Y, Tonelli F, Padmanabhan S, Baptista MAS, Riley L, Smith D, Marras C, Howden A, Alessi DR, Sammler E. Fan Y, et al. Among authors: tonelli f. J Vis Exp. 2020 Mar 21;(157). doi: 10.3791/58956. J Vis Exp. 2020. PMID: 32250352

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