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Platelets subvert T cell immunity against cancer via GARP-TGFβ axis.
Rachidi S, Metelli A, Riesenberg B, Wu BX, Nelson MH, Wallace C, Paulos CM, Rubinstein MP, Garrett-Mayer E, Hennig M, Bearden DW, Yang Y, Liu B, Li Z. Rachidi S, et al. Among authors: wu bx. Sci Immunol. 2017 May 5;2(11):eaai7911. doi: 10.1126/sciimmunol.aai7911. Sci Immunol. 2017. PMID: 28763790 Free PMC article.
B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex.
Wallace CH, Wu BX, Salem M, Ansa-Addo EA, Metelli A, Sun S, Gilkeson G, Shlomchik MJ, Liu B, Li Z. Wallace CH, et al. Among authors: wu bx. JCI Insight. 2018 Apr 5;3(7):e99863. doi: 10.1172/jci.insight.99863. eCollection 2018 Apr 5. JCI Insight. 2018. PMID: 29618665 Free PMC article.
Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β.
Metelli A, Wu BX, Riesenberg B, Guglietta S, Huck JD, Mills C, Li A, Rachidi S, Krieg C, Rubinstein MP, Gewirth DT, Sun S, Lilly MB, Wahlquist AH, Carbone DP, Yang Y, Liu B, Li Z. Metelli A, et al. Among authors: wu bx. Sci Transl Med. 2020 Jan 8;12(525):eaay4860. doi: 10.1126/scitranslmed.aay4860. Sci Transl Med. 2020. PMID: 31915300 Free PMC article.
GP96 is a GARP chaperone and controls regulatory T cell functions.
Zhang Y, Wu BX, Metelli A, Thaxton JE, Hong F, Rachidi S, Ansa-Addo E, Sun S, Vasu C, Yang Y, Liu B, Li Z. Zhang Y, et al. Among authors: wu bx. J Clin Invest. 2015 Feb;125(2):859-69. doi: 10.1172/JCI79014. Epub 2015 Jan 20. J Clin Invest. 2015. PMID: 25607841 Free PMC article.
Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94.
Ansa-Addo EA, Thaxton J, Hong F, Wu BX, Zhang Y, Fugle CW, Metelli A, Riesenberg B, Williams K, Gewirth DT, Chiosis G, Liu B, Li Z. Ansa-Addo EA, et al. Among authors: wu bx. Curr Top Med Chem. 2016;16(25):2765-78. doi: 10.2174/1568026616666160413141613. Curr Top Med Chem. 2016. PMID: 27072698 Free PMC article. Review.
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