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Page 1
Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines.
Woerman AL, Oehler A, Kazmi SA, Lee J, Halliday GM, Middleton LT, Gentleman SM, Mordes DA, Spina S, Grinberg LT, Olson SH, Prusiner SB. Woerman AL, et al. Among authors: middleton lt. Acta Neuropathol. 2019 Mar;137(3):437-454. doi: 10.1007/s00401-019-01959-4. Epub 2019 Jan 28. Acta Neuropathol. 2019. PMID: 30690664 Free PMC article.
Propagation of prions causing synucleinopathies in cultured cells.
Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K, Prusiner SB. Woerman AL, et al. Among authors: middleton lt. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4949-58. doi: 10.1073/pnas.1513426112. Epub 2015 Aug 18. Proc Natl Acad Sci U S A. 2015. PMID: 26286986 Free PMC article.
Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.
Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K. Prusiner SB, et al. Among authors: middleton lt. Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5308-17. doi: 10.1073/pnas.1514475112. Epub 2015 Aug 31. Proc Natl Acad Sci U S A. 2015. PMID: 26324905 Free PMC article.
α-Synuclein: Multiple System Atrophy Prions.
Woerman AL, Watts JC, Aoyagi A, Giles K, Middleton LT, Prusiner SB. Woerman AL, et al. Among authors: middleton lt. Cold Spring Harb Perspect Med. 2018 Jul 2;8(7):a024588. doi: 10.1101/cshperspect.a024588. Cold Spring Harb Perspect Med. 2018. PMID: 28213437 Free PMC article. Review.
MSA prions exhibit remarkable stability and resistance to inactivation.
Woerman AL, Kazmi SA, Patel S, Freyman Y, Oehler A, Aoyagi A, Mordes DA, Halliday GM, Middleton LT, Gentleman SM, Olson SH, Prusiner SB. Woerman AL, et al. Among authors: middleton lt. Acta Neuropathol. 2018 Jan;135(1):49-63. doi: 10.1007/s00401-017-1762-2. Epub 2017 Aug 28. Acta Neuropathol. 2018. PMID: 28849371 Free PMC article.
Transmission of multiple system atrophy prions to transgenic mice.
Watts JC, Giles K, Oehler A, Middleton L, Dexter DT, Gentleman SM, DeArmond SJ, Prusiner SB. Watts JC, et al. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19555-60. doi: 10.1073/pnas.1318268110. Epub 2013 Nov 11. Proc Natl Acad Sci U S A. 2013. PMID: 24218576 Free PMC article.
Cortical Lewy bodies and Aβ burden are associated with prevalence and timing of dementia in Lewy body diseases.
Ruffmann C, Calboli FC, Bravi I, Gveric D, Curry LK, de Smith A, Pavlou S, Buxton JL, Blakemore AI, Takousis P, Molloy S, Piccini P, Dexter DT, Roncaroli F, Gentleman SM, Middleton LT. Ruffmann C, et al. Among authors: middleton lt. Neuropathol Appl Neurobiol. 2016 Aug;42(5):436-50. doi: 10.1111/nan.12294. Epub 2015 Dec 2. Neuropathol Appl Neurobiol. 2016. PMID: 26527105 Free article.
Alzheimer's disease pathology explains association between dementia with Lewy bodies and APOE-ε4/TOMM40 long poly-T repeat allele variants.
Prokopenko I, Miyakawa G, Zheng B, Heikkinen J, Petrova Quayle D, Udeh-Momoh C, Claringbould A, Neumann J, Haytural H, Kaakinen MA, Loizidou E, Meissner E, Bertram L; BIOS consortium; Gveric DO, Gentleman SM, Attems J, Perneczky R, Arzberger T, Muglia P, Lill CM, Parkkinen L, Middleton LT. Prokopenko I, et al. Among authors: middleton lt. Alzheimers Dement (N Y). 2019 Nov 20;5:814-824. doi: 10.1016/j.trci.2019.08.005. eCollection 2019. Alzheimers Dement (N Y). 2019. PMID: 31788537 Free PMC article.
α-synuclein genetic variability: A biomarker for dementia in Parkinson disease.
Guella I, Evans DM, Szu-Tu C, Nosova E, Bortnick SF; SNCA Cognition Study Group; Goldman JG, Dalrymple-Alford JC, Geurtsen GJ, Litvan I, Ross OA, Middleton LT, Parkkinen L, Farrer MJ. Guella I, et al. Among authors: middleton lt. Ann Neurol. 2016 Jun;79(6):991-9. doi: 10.1002/ana.24664. Epub 2016 May 5. Ann Neurol. 2016. PMID: 27091628 Free article.
Parkinson's Disease Case Ascertainment in the EPIC Cohort: The NeuroEPIC4PD Study.
Gallo V, Brayne C, Forsgren L, Barker RA, Petersson J, Hansson O, Lindqvist D, Ruffmann C, Ishihara L, Luben R, Arriola L, Bergareche A, Gavrila D, Erro ME, Vanacore N, Sacerdote C, Bueno-de-Mesquita B, Vermeulen R, Seelen M, Sieri S, Masala G, Ramat S, Kyrozis A, Thricopolou A, Panico S, Mattiello A, Kaaks R, Teucher B, Katzke V, Kloss M, Curry L, Calboli F, Riboli E, Vineis P, Middleton L. Gallo V, et al. Neurodegener Dis. 2015;15(6):331-8. doi: 10.1159/000381857. Epub 2015 Sep 17. Neurodegener Dis. 2015. PMID: 26375921 Clinical Trial.
160 results