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The curcumin analog EF24 is a novel senolytic agent.
Li W, He Y, Zhang R, Zheng G, Zhou D. Li W, et al. Among authors: he y. Aging (Albany NY). 2019 Jan 28;11(2):771-782. doi: 10.18632/aging.101787. Aging (Albany NY). 2019. PMID: 30694217 Free PMC article.
Oxidation resistance 1 is a novel senolytic target.
Zhang X, Zhang S, Liu X, Wang Y, Chang J, Zhang X, Mackintosh SG, Tackett AJ, He Y, Lv D, Laberge RM, Campisi J, Wang J, Zheng G, Zhou D. Zhang X, et al. Among authors: he y. Aging Cell. 2018 Aug;17(4):e12780. doi: 10.1111/acel.12780. Epub 2018 May 15. Aging Cell. 2018. PMID: 29766639 Free PMC article.
Cellular senescence and radiation-induced pulmonary fibrosis.
He Y, Thummuri D, Zheng G, Okunieff P, Citrin DE, Vujaskovic Z, Zhou D. He Y, et al. Transl Res. 2019 Jul;209:14-21. doi: 10.1016/j.trsl.2019.03.006. Epub 2019 Mar 27. Transl Res. 2019. PMID: 30981698 Free PMC article. Review.
Emerging senolytic agents derived from natural products.
Li W, Qin L, Feng R, Hu G, Sun H, He Y, Zhang R. Li W, et al. Among authors: he y. Mech Ageing Dev. 2019 Jul;181:1-6. doi: 10.1016/j.mad.2019.05.001. Epub 2019 May 8. Mech Ageing Dev. 2019. PMID: 31077707 Review.
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity.
Khan S, Zhang X, Lv D, Zhang Q, He Y, Zhang P, Liu X, Thummuri D, Yuan Y, Wiegand JS, Pei J, Zhang W, Sharma A, McCurdy CR, Kuruvilla VM, Baran N, Ferrando AA, Kim YM, Rogojina A, Houghton PJ, Huang G, Hromas R, Konopleva M, Zheng G, Zhou D. Khan S, et al. Among authors: he y. Nat Med. 2019 Dec;25(12):1938-1947. doi: 10.1038/s41591-019-0668-z. Epub 2019 Dec 2. Nat Med. 2019. PMID: 31792461 Free PMC article.
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity.
He Y, Zhang X, Chang J, Kim HN, Zhang P, Wang Y, Khan S, Liu X, Zhang X, Lv D, Song L, Li W, Thummuri D, Yuan Y, Wiegand JS, Ortiz YT, Budamagunta V, Elisseeff JH, Campisi J, Almeida M, Zheng G, Zhou D. He Y, et al. Nat Commun. 2020 Apr 24;11(1):1996. doi: 10.1038/s41467-020-15838-0. Nat Commun. 2020. PMID: 32332723 Free PMC article.
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