Śledź P - Search Results

1

A Reader-Based Assay for m⁶A Writers and Erasers.

Wiedmer L, Eberle SA, Bedi RK, Śledź P, Caflisch A. Wiedmer L, et al. Among authors: sledz p. Anal Chem. 2019 Feb 19;91(4):3078-3084. doi: 10.1021/acs.analchem.8b05500. Epub 2019 Feb 4. Anal Chem. 2019. PMID: 30715855

2

Flexible Binding of m⁶A Reader Protein YTHDC1 to Its Preferred RNA Motif.

Li Y, Bedi RK, Wiedmer L, Huang D, Śledź P, Caflisch A. Li Y, et al. Among authors: sledz p. J Chem Theory Comput. 2019 Dec 10;15(12):7004-7014. doi: 10.1021/acs.jctc.9b00987. Epub 2019 Nov 14. J Chem Theory Comput. 2019. PMID: 31670957

3

Selectively Disrupting m⁶A-Dependent Protein-RNA Interactions with Fragments.

Bedi RK, Huang D, Wiedmer L, Li Y, Dolbois A, Wojdyla JA, Sharpe ME, Caflisch A, Sledz P. Bedi RK, et al. Among authors: sledz p. ACS Chem Biol. 2020 Mar 20;15(3):618-625. doi: 10.1021/acschembio.9b00894. Epub 2020 Mar 2. ACS Chem Biol. 2020. PMID: 32101404

4

Protein structure-based drug design: from docking to molecular dynamics.

Śledź P, Caflisch A. Śledź P, et al. Curr Opin Struct Biol. 2018 Feb;48:93-102. doi: 10.1016/j.sbi.2017.10.010. Epub 2017 Nov 14. Curr Opin Struct Biol. 2018. PMID: 29149726 Review.

5

Ligand retargeting by binding site analogy.

Wiedmer L, Schärer C, Spiliotopoulos D, Hürzeler M, Śledź P, Caflisch A. Wiedmer L, et al. Among authors: sledz p. Eur J Med Chem. 2019 Aug 1;175:107-113. doi: 10.1016/j.ejmech.2019.04.037. Epub 2019 Apr 25. Eur J Med Chem. 2019. PMID: 31077996

6

Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer.

Bedi RK, Huang D, Eberle SA, Wiedmer L, Śledź P, Caflisch A. Bedi RK, et al. Among authors: sledz p. ChemMedChem. 2020 May 6;15(9):744-748. doi: 10.1002/cmdc.202000011. Epub 2020 Mar 23. ChemMedChem. 2020. PMID: 32159918

7

Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers.

Dolbois A, Batiste L, Wiedmer L, Dong J, Brütsch M, Huang D, Deerain NM, Spiliotopoulos D, Cheng-Sánchez I, Laul E, Nevado C, Śledź P, Caflisch A. Dolbois A, et al. Among authors: sledz p. ACS Med Chem Lett. 2020 Jun 30;11(8):1573-1580. doi: 10.1021/acsmedchemlett.0c00080. eCollection 2020 Aug 13. ACS Med Chem Lett. 2020. PMID: 32832026 Free PMC article.

8

Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.

Zhu J, Dong J, Batiste L, Unzue A, Dolbois A, Pascanu V, Śledź P, Nevado C, Caflisch A. Zhu J, et al. Among authors: sledz p. ACS Med Chem Lett. 2018 Aug 8;9(9):929-934. doi: 10.1021/acsmedchemlett.8b00286. eCollection 2018 Sep 13. ACS Med Chem Lett. 2018. PMID: 30258543 Free PMC article.

9

Understanding the mechanism of action of pyrrolo[3,2-b]quinoxaline-derivatives as kinase inhibitors.

Unzue A, Jessen-Trefzer C, Spiliotopoulos D, Gaudio E, Tarantelli C, Dong J, Zhao H, Pachmayr J, Zahler S, Bernasconi E, Sartori G, Cascione L, Bertoni F, Śledź P, Caflisch A, Nevado C. Unzue A, et al. Among authors: sledz p. RSC Med Chem. 2020 May 19;11(6):665-675. doi: 10.1039/d0md00049c. eCollection 2020 Jun 1. RSC Med Chem. 2020. PMID: 33479666 Free PMC article.

10

Structural insights into the molecular mechanism of the m(6)A writer complex.

Śledź P, Jinek M. Śledź P, et al. Elife. 2016 Sep 14;5:e18434. doi: 10.7554/eLife.18434. Elife. 2016. PMID: 27627798 Free PMC article.

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