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Small-molecule allosteric inhibitors of BAX.
Garner TP, Amgalan D, Reyna DE, Li S, Kitsis RN, Gavathiotis E. Garner TP, et al. Among authors: gavathiotis e. Nat Chem Biol. 2019 Apr;15(4):322-330. doi: 10.1038/s41589-018-0223-0. Epub 2019 Feb 4. Nat Chem Biol. 2019. PMID: 30718816 Free PMC article.
BAX activation is initiated at a novel interaction site.
Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD. Gavathiotis E, et al. Nature. 2008 Oct 23;455(7216):1076-81. doi: 10.1038/nature07396. Nature. 2008. PMID: 18948948 Free PMC article.
Bax regulates primary necrosis through mitochondrial dynamics.
Whelan RS, Konstantinidis K, Wei AC, Chen Y, Reyna DE, Jha S, Yang Y, Calvert JW, Lindsten T, Thompson CB, Crow MT, Gavathiotis E, Dorn GW 2nd, O'Rourke B, Kitsis RN. Whelan RS, et al. Among authors: gavathiotis e. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6566-71. doi: 10.1073/pnas.1201608109. Epub 2012 Apr 9. Proc Natl Acad Sci U S A. 2012. PMID: 22493254 Free PMC article.
Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.
Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD. Barclay LA, et al. Among authors: gavathiotis e. Mol Cell. 2015 Mar 5;57(5):873-886. doi: 10.1016/j.molcel.2015.01.014. Epub 2015 Feb 12. Mol Cell. 2015. PMID: 25684204 Free PMC article.
91 results