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NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease.
Myakala K, Wang XX, Shults NV, Krawczyk E, Jones BA, Yang X, Rosenberg AZ, Ginley B, Sarder P, Brodsky L, Jang Y, Na CH, Qi Y, Zhang X, Guha U, Wu C, Bansal S, Ma J, Cheema A, Albanese C, Hirschey MD, Yoshida T, Kopp JB, Panov J, Levi M. Myakala K, et al. Among authors: hirschey md. J Biol Chem. 2023 Aug;299(8):104975. doi: 10.1016/j.jbc.2023.104975. Epub 2023 Jul 8. J Biol Chem. 2023. PMID: 37429506 Free PMC article.
Statin therapy inhibits fatty acid synthase via dynamic protein modifications.
Trub AG, Wagner GR, Anderson KA, Crown SB, Zhang GF, Thompson JW, Ilkayeva OR, Stevens RD, Grimsrud PA, Kulkarni RA, Backos DS, Meier JL, Hirschey MD. Trub AG, et al. Among authors: hirschey md. Nat Commun. 2022 May 10;13(1):2542. doi: 10.1038/s41467-022-30060-w. Nat Commun. 2022. PMID: 35538051 Free PMC article.
Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice.
Bhatt DP, Mills CA, Anderson KA, Henriques BJ, Lucas TG, Francisco S, Liu J, Ilkayeva OR, Adams AE, Kulkarni SR, Backos DS, Major MB, Grimsrud PA, Gomes CM, Hirschey MD. Bhatt DP, et al. Among authors: hirschey md. J Biol Chem. 2022 Apr;298(4):101723. doi: 10.1016/j.jbc.2022.101723. Epub 2022 Feb 12. J Biol Chem. 2022. PMID: 35157847 Free PMC article.
Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans.
Hershberger KA, Rooney JP, Turner EA, Donoghue LJ, Bodhicharla R, Maurer LL, Ryde IT, Kim JJ, Joglekar R, Hibshman JD, Smith LL, Bhatt DP, Ilkayeva OR, Hirschey MD, Meyer JN. Hershberger KA, et al. Among authors: hirschey md. Redox Biol. 2021 Jul;43:102000. doi: 10.1016/j.redox.2021.102000. Epub 2021 May 5. Redox Biol. 2021. PMID: 33993056 Free PMC article.
Discovering the landscape of protein modifications.
Keenan EK, Zachman DK, Hirschey MD. Keenan EK, et al. Among authors: hirschey md. Mol Cell. 2021 May 6;81(9):1868-1878. doi: 10.1016/j.molcel.2021.03.015. Epub 2021 Apr 1. Mol Cell. 2021. PMID: 33798408 Free PMC article. Review.
87 results