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Absence of adaptive evolution is the main barrier against influenza emergence in horses in Asia despite frequent virus interspecies transmission from wild birds.
Zhu H, Damdinjav B, Gonzalez G, Patrono LV, Ramirez-Mendoza H, Amat JAR, Crispell J, Parr YA, Hammond TA, Shiilegdamba E, Leung YHC, Peiris M, Marshall JF, Hughes J, Gilbert M, Murcia PR. Zhu H, et al. Among authors: marshall jf. PLoS Pathog. 2019 Feb 7;15(2):e1007531. doi: 10.1371/journal.ppat.1007531. eCollection 2019 Feb. PLoS Pathog. 2019. PMID: 30731004 Free PMC article.
Mammalian Adaptation of an Avian Influenza A Virus Involves Stepwise Changes in NS1.
Chauché C, Nogales A, Zhu H, Goldfarb D, Ahmad Shanizza AI, Gu Q, Parrish CR, Martínez-Sobrido L, Marshall JF, Murcia PR. Chauché C, et al. Among authors: marshall jf. J Virol. 2018 Feb 12;92(5):e01875-17. doi: 10.1128/JVI.01875-17. Print 2018 Mar 1. J Virol. 2018. PMID: 29237841 Free PMC article.
Long-term adaptation following influenza A virus host shifts results in increased within-host viral fitness due to higher replication rates, broader dissemination within the respiratory epithelium and reduced tissue damage.
Amat JAR, Patton V, Chauché C, Goldfarb D, Crispell J, Gu Q, Coburn AM, Gonzalez G, Mair D, Tong L, Martinez-Sobrido L, Marshall JF, Marchesi F, Murcia PR. Amat JAR, et al. Among authors: marshall jf. PLoS Pathog. 2021 Dec 17;17(12):e1010174. doi: 10.1371/journal.ppat.1010174. eCollection 2021 Dec. PLoS Pathog. 2021. PMID: 34919598 Free PMC article.
338 results