Schwartz TW - Search Results

1

Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.

Chen S, Lu M, Liu D, Yang L, Yi C, Ma L, Zhang H, Liu Q, Frimurer TM, Wang MW, Schwartz TW, Stevens RC, Wu B, Wüthrich K, Zhao Q. Chen S, et al. Among authors: schwartz tw. Nat Commun. 2019 Feb 7;10(1):638. doi: 10.1038/s41467-019-08568-5. Nat Commun. 2019. PMID: 30733446 Free PMC article.

2

Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor.

Elling CE, Nielsen SM, Schwartz TW. Elling CE, et al. Among authors: schwartz tw. Nature. 1995 Mar 2;374(6517):74-7. doi: 10.1038/374074a0. Nature. 1995. PMID: 7532789

3

Different binding epitopes on the NK1 receptor for substance P and non-peptide antagonist.

Gether U, Johansen TE, Snider RM, Lowe JA 3rd, Nakanishi S, Schwartz TW. Gether U, et al. Among authors: schwartz tw. Nature. 1993 Mar 25;362(6418):345-8. doi: 10.1038/362345a0. Nature. 1993. PMID: 7681152

4

Molecular mechanism of 7TM receptor activation--a global toggle switch model.

Schwartz TW, Frimurer TM, Holst B, Rosenkilde MM, Elling CE. Schwartz TW, et al. Annu Rev Pharmacol Toxicol. 2006;46:481-519. doi: 10.1146/annurev.pharmtox.46.120604.141218. Annu Rev Pharmacol Toxicol. 2006. PMID: 16402913 Review.

5

Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation.

Elling CE, Frimurer TM, Gerlach LO, Jorgensen R, Holst B, Schwartz TW. Elling CE, et al. Among authors: schwartz tw. J Biol Chem. 2006 Jun 23;281(25):17337-17346. doi: 10.1074/jbc.M512510200. Epub 2006 Mar 27. J Biol Chem. 2006. PMID: 16567806 Free article.

6

Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor.

Holst B, Lang M, Brandt E, Bach A, Howard A, Frimurer TM, Beck-Sickinger A, Schwartz TW. Holst B, et al. Among authors: schwartz tw. Mol Pharmacol. 2006 Sep;70(3):936-46. doi: 10.1124/mol.106.024422. Epub 2006 Jun 23. Mol Pharmacol. 2006. PMID: 16798937

7

Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI.

Rosenkilde MM, Andersen MB, Nygaard R, Frimurer TM, Schwartz TW. Rosenkilde MM, et al. Among authors: schwartz tw. Mol Pharmacol. 2007 Mar;71(3):930-41. doi: 10.1124/mol.106.030031. Epub 2006 Dec 14. Mol Pharmacol. 2007. PMID: 17170198

8

Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism.

Holst B, Mokrosinski J, Lang M, Brandt E, Nygaard R, Frimurer TM, Beck-Sickinger AG, Schwartz TW. Holst B, et al. Among authors: schwartz tw. J Biol Chem. 2007 May 25;282(21):15799-811. doi: 10.1074/jbc.M609796200. Epub 2007 Mar 19. J Biol Chem. 2007. PMID: 17371869 Free article.

9

Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor.

Holst B, Frimurer TM, Mokrosinski J, Halkjaer T, Cullberg KB, Underwood CR, Schwartz TW. Holst B, et al. Among authors: schwartz tw. Mol Pharmacol. 2009 Jan;75(1):44-59. doi: 10.1124/mol.108.049189. Epub 2008 Oct 15. Mol Pharmacol. 2009. PMID: 18923064

10

Ligand binding and micro-switches in 7TM receptor structures.

Nygaard R, Frimurer TM, Holst B, Rosenkilde MM, Schwartz TW. Nygaard R, et al. Among authors: schwartz tw. Trends Pharmacol Sci. 2009 May;30(5):249-59. doi: 10.1016/j.tips.2009.02.006. Epub 2009 Apr 16. Trends Pharmacol Sci. 2009. PMID: 19375807 Review.

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