Price IR - Search Results

1

A Small-Molecule SIRT2 Inhibitor That Promotes K-Ras4a Lysine Fatty-Acylation.

Spiegelman NA, Hong JY, Hu J, Jing H, Wang M, Price IR, Cao J, Yang M, Zhang X, Lin H. Spiegelman NA, et al. Among authors: price ir. ChemMedChem. 2019 Apr 3;14(7):744-748. doi: 10.1002/cmdc.201800715. Epub 2019 Feb 25. ChemMedChem. 2019. PMID: 30734528 Free PMC article.

2

A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors.

Hong JY, Price IR, Bai JJ, Lin H. Hong JY, et al. Among authors: price ir. ACS Chem Biol. 2019 Aug 16;14(8):1802-1810. doi: 10.1021/acschembio.9b00384. Epub 2019 Aug 2. ACS Chem Biol. 2019. PMID: 31373792 Free PMC article.

3

Golgi stress induces SIRT2 to counteract Shigella infection via defatty-acylation.

Wang M, Zhang Y, Komaniecki GP, Lu X, Cao J, Zhang M, Yu T, Hou D, Spiegelman NA, Yang M, Price IR, Lin H. Wang M, et al. Among authors: price ir. Nat Commun. 2022 Aug 2;13(1):4494. doi: 10.1038/s41467-022-32227-x. Nat Commun. 2022. PMID: 35918380 Free PMC article.

4

Direct Comparison of SIRT2 Inhibitors: Potency, Specificity, Activity-Dependent Inhibition, and On-Target Anticancer Activities.

Spiegelman NA, Price IR, Jing H, Wang M, Yang M, Cao J, Hong JY, Zhang X, Aramsangtienchai P, Sadhukhan S, Lin H. Spiegelman NA, et al. Among authors: price ir. ChemMedChem. 2018 Sep 19;13(18):1890-1894. doi: 10.1002/cmdc.201800391. Epub 2018 Aug 13. ChemMedChem. 2018. PMID: 30058233 Free PMC article.

5

Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.

Farooqi AS, Hong JY, Cao J, Lu X, Price IR, Zhao Q, Kosciuk T, Yang M, Bai JJ, Lin H. Farooqi AS, et al. Among authors: price ir. J Med Chem. 2019 Apr 25;62(8):4131-4141. doi: 10.1021/acs.jmedchem.9b00191. Epub 2019 Apr 15. J Med Chem. 2019. PMID: 30986062 Free PMC article.

6

Simultaneous Inhibition of SIRT2 Deacetylase and Defatty-Acylase Activities via a PROTAC Strategy.

Hong JY, Jing H, Price IR, Cao J, Bai JJ, Lin H. Hong JY, et al. Among authors: price ir. ACS Med Chem Lett. 2020 Sep 21;11(11):2305-2311. doi: 10.1021/acsmedchemlett.0c00423. eCollection 2020 Nov 12. ACS Med Chem Lett. 2020. PMID: 33214845 Free PMC article.

7

NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle.

Kosciuk T, Price IR, Zhang X, Zhu C, Johnson KN, Zhang S, Halaby SL, Komaniecki GP, Yang M, DeHart CJ, Thomas PM, Kelleher NL, Fromme JC, Lin H. Kosciuk T, et al. Among authors: price ir. Nat Commun. 2020 Feb 26;11(1):1067. doi: 10.1038/s41467-020-14893-x. Nat Commun. 2020. PMID: 32103017 Free PMC article.

8

Binding Affinity Determines Substrate Specificity and Enables Discovery of Substrates for N-Myristoyltransferases.

Su D, Kosciuk T, Yang M, Price IR, Lin H. Su D, et al. Among authors: price ir. ACS Catal. 2021 Dec 17;11(24):14877-14883. doi: 10.1021/acscatal.1c03330. Epub 2021 Nov 29. ACS Catal. 2021. PMID: 34956690 Free PMC article.

9

Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis.

Zhang S, Nelson OD, Price IR, Zhu C, Lu X, Fernandez IR, Weiss RS, Lin H. Zhang S, et al. Among authors: price ir. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2117013119. doi: 10.1073/pnas.2117013119. Epub 2022 Mar 8. Proc Natl Acad Sci U S A. 2022. PMID: 35259022 Free PMC article.

10

Local-to-global signal transduction at the core of a Mn²⁺ sensing riboswitch.

Suddala KC, Price IR, Dandpat SS, Janeček M, Kührová P, Šponer J, Banáš P, Ke A, Walter NG. Suddala KC, et al. Among authors: price ir. Nat Commun. 2019 Sep 20;10(1):4304. doi: 10.1038/s41467-019-12230-5. Nat Commun. 2019. PMID: 31541094 Free PMC article.

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