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A mouse model that recapitulates cardinal features of the 15q13.3 microdeletion syndrome including schizophrenia- and epilepsy-related alterations.
Fejgin K, Nielsen J, Birknow MR, Bastlund JF, Nielsen V, Lauridsen JB, Stefansson H, Steinberg S, Sorensen HB, Mortensen TE, Larsen PH, Klewe IV, Rasmussen SV, Stefansson K, Werge TM, Kallunki P, Christensen KV, Didriksen M. Fejgin K, et al. Among authors: bastlund jf. Biol Psychiatry. 2014 Jul 15;76(2):128-37. doi: 10.1016/j.biopsych.2013.08.014. Epub 2013 Oct 3. Biol Psychiatry. 2014. PMID: 24090792
The 5-HT6 receptor antagonist idalopirdine potentiates the effects of acetylcholinesterase inhibition on neuronal network oscillations and extracellular acetylcholine levels in the rat dorsal hippocampus.
Herrik KF, Mørk A, Richard N, Bundgaard C, Bastlund JF, de Jong IEM. Herrik KF, et al. Among authors: bastlund jf. Neuropharmacology. 2016 Aug;107:351-363. doi: 10.1016/j.neuropharm.2016.03.043. Epub 2016 Mar 31. Neuropharmacology. 2016. PMID: 27039041 Free article.
The 5-HT6 receptor antagonist idalopirdine potentiates the effects of donepezil on gamma oscillations in the frontal cortex of anesthetized and awake rats without affecting sleep-wake architecture.
Amat-Foraster M, Leiser SC, Herrik KF, Richard N, Agerskov C, Bundgaard C, Bastlund JF, de Jong IEM. Amat-Foraster M, et al. Among authors: bastlund jf. Neuropharmacology. 2017 Feb;113(Pt A):45-59. doi: 10.1016/j.neuropharm.2016.09.017. Epub 2016 Sep 16. Neuropharmacology. 2017. PMID: 27647493 Free article.
A small molecule activator of Nav 1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo.
Frederiksen K, Lu D, Yang J, Jensen HS, Bastlund JF, Larsen PH, Liu H, Crestey F, Dekermendjian K, Badolo L, Laursen M, Hougaard C, Yang C, Svenstrup N, Grunnet M. Frederiksen K, et al. Among authors: bastlund jf. Eur J Neurosci. 2017 Aug;46(3):1887-1896. doi: 10.1111/ejn.13626. Epub 2017 Jul 20. Eur J Neurosci. 2017. PMID: 28635024
53 results