Cornea RL - Search Results

1

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic.

Batiste SM, Blackwell DJ, Kim K, Kryshtal DO, Gomez-Hurtado N, Rebbeck RT, Cornea RL, Johnston JN, Knollmann BC. Batiste SM, et al. Among authors: cornea rl. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4810-4815. doi: 10.1073/pnas.1816685116. Epub 2019 Feb 21. Proc Natl Acad Sci U S A. 2019. PMID: 30792355 Free PMC article.

2

FRET-based mapping of calmodulin bound to the RyR1 Ca2+ release channel.

Cornea RL, Nitu F, Gruber S, Kohler K, Satzer M, Thomas DD, Fruen BR. Cornea RL, et al. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6128-33. doi: 10.1073/pnas.0813010106. Epub 2009 Mar 30. Proc Natl Acad Sci U S A. 2009. PMID: 19332786 Free PMC article.

3

Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants.

Hwang HS, Nitu FR, Yang Y, Walweel K, Pereira L, Johnson CN, Faggioni M, Chazin WJ, Laver D, George AL Jr, Cornea RL, Bers DM, Knollmann BC. Hwang HS, et al. Among authors: cornea rl. Circ Res. 2014 Mar 28;114(7):1114-24. doi: 10.1161/CIRCRESAHA.114.303391. Epub 2014 Feb 21. Circ Res. 2014. PMID: 24563457 Free PMC article.

4

Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.

Oda T, Yang Y, Uchinoumi H, Thomas DD, Chen-Izu Y, Kato T, Yamamoto T, Yano M, Cornea RL, Bers DM. Oda T, et al. Among authors: cornea rl. J Mol Cell Cardiol. 2015 Aug;85:240-8. doi: 10.1016/j.yjmcc.2015.06.009. Epub 2015 Jun 16. J Mol Cell Cardiol. 2015. PMID: 26092277 Free PMC article.

5

S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.

Rebbeck RT, Nitu FR, Rohde D, Most P, Bers DM, Thomas DD, Cornea RL. Rebbeck RT, et al. Among authors: cornea rl. J Biol Chem. 2016 Jul 22;291(30):15896-907. doi: 10.1074/jbc.M115.713107. Epub 2016 May 19. J Biol Chem. 2016. PMID: 27226555 Free PMC article.

6

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.

Gomez-Hurtado N, Boczek NJ, Kryshtal DO, Johnson CN, Sun J, Nitu FR, Cornea RL, Chazin WJ, Calvert ML, Tester DJ, Ackerman MJ, Knollmann BC. Gomez-Hurtado N, et al. Among authors: cornea rl. Circ Arrhythm Electrophysiol. 2016 Aug;9(8):10.1161/CIRCEP.116.004161 e004161. doi: 10.1161/CIRCEP.116.004161. Circ Arrhythm Electrophysiol. 2016. PMID: 27516456 Free PMC article.

7

High-Throughput Screens to Discover Small-Molecule Modulators of Ryanodine Receptor Calcium Release Channels.

Rebbeck RT, Essawy MM, Nitu FR, Grant BD, Gillispie GD, Thomas DD, Bers DM, Cornea RL. Rebbeck RT, et al. Among authors: cornea rl. SLAS Discov. 2017 Feb;22(2):176-186. doi: 10.1177/1087057116674312. Epub 2016 Oct 22. SLAS Discov. 2017. PMID: 27760856 Free PMC article.

8

Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814.

Walweel K, Gomez-Hurtado N, Rebbeck RT, Oo YW, Beard NA, Molenaar P, Dos Remedios C, van Helden DF, Cornea RL, Knollmann BC, Laver DR. Walweel K, et al. Among authors: cornea rl. J Mol Cell Cardiol. 2019 May;130:96-106. doi: 10.1016/j.yjmcc.2019.03.018. Epub 2019 Mar 27. J Mol Cell Cardiol. 2019. PMID: 30928430 Free PMC article.

9

The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of Na_V1.5 and RyR2 function.

Johnson CN, Pattanayek R, Potet F, Rebbeck RT, Blackwell DJ, Nikolaienko R, Sequeira V, Le Meur R, Radwański PB, Davis JP, Zima AV, Cornea RL, Damo SM, Györke S, George AL Jr, Knollmann BC. Johnson CN, et al. Among authors: cornea rl. Cell Calcium. 2019 Sep;82:102063. doi: 10.1016/j.ceca.2019.102063. Epub 2019 Jul 30. Cell Calcium. 2019. PMID: 31401388 Free PMC article.

10

Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators.

Lindsay A, Baumann CW, Rebbeck RT, Yuen SL, Southern WM, Hodges JS, Cornea RL, Thomas DD, Ervasti JM, Lowe DA. Lindsay A, et al. Among authors: cornea rl. Skelet Muscle. 2020 Feb 1;10(1):3. doi: 10.1186/s13395-020-0221-2. Skelet Muscle. 2020. PMID: 32007101 Free PMC article.

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