Flagmeier P - Search Results

1

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.

Weiffert T, Meisl G, Flagmeier P, De S, Dunning CJR, Frohm B, Zetterberg H, Blennow K, Portelius E, Klenerman D, Dobson CM, Knowles TPJ, Linse S. Weiffert T, et al. Among authors: flagmeier p. ACS Chem Neurosci. 2019 May 15;10(5):2374-2384. doi: 10.1021/acschemneuro.8b00676. Epub 2019 Mar 8. ACS Chem Neurosci. 2019. PMID: 30793584

2

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates.

Chia S, Flagmeier P, Habchi J, Lattanzi V, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M. Chia S, et al. Among authors: flagmeier p. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8005-8010. doi: 10.1073/pnas.1700239114. Epub 2017 Jul 11. Proc Natl Acad Sci U S A. 2017. PMID: 28698377 Free PMC article.

3

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity.

Kundel F, De S, Flagmeier P, Horrocks MH, Kjaergaard M, Shammas SL, Jackson SE, Dobson CM, Klenerman D. Kundel F, et al. Among authors: flagmeier p. ACS Chem Biol. 2018 Mar 16;13(3):636-646. doi: 10.1021/acschembio.7b01039. Epub 2018 Jan 17. ACS Chem Biol. 2018. PMID: 29300447 Free PMC article.

4

Quantifying Co-Oligomer Formation by α-Synuclein.

Iljina M, Dear AJ, Garcia GA, De S, Tosatto L, Flagmeier P, Whiten DR, Michaels TCT, Frenkel D, Dobson CM, Knowles TPJ, Klenerman D. Iljina M, et al. Among authors: flagmeier p. ACS Nano. 2018 Nov 27;12(11):10855-10866. doi: 10.1021/acsnano.8b03575. Epub 2018 Oct 29. ACS Nano. 2018. PMID: 30371053 Free PMC article.

5

Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation.

Flagmeier P, De S, Michaels TCT, Yang X, Dear AJ, Emanuelsson C, Vendruscolo M, Linse S, Klenerman D, Knowles TPJ, Dobson CM. Flagmeier P, et al. Nat Struct Mol Biol. 2020 Oct;27(10):886-891. doi: 10.1038/s41594-020-0471-z. Epub 2020 Aug 10. Nat Struct Mol Biol. 2020. PMID: 32778821

6

Protein microgels from amyloid fibril networks.

Shimanovich U, Efimov I, Mason TO, Flagmeier P, Buell AK, Gedanken A, Linse S, Åkerfeldt KS, Dobson CM, Weitz DA, Knowles TP. Shimanovich U, et al. Among authors: flagmeier p. ACS Nano. 2015 Jan 27;9(1):43-51. doi: 10.1021/nn504869d. Epub 2015 Jan 12. ACS Nano. 2015. PMID: 25469621

7

Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.

Flagmeier P, Meisl G, Vendruscolo M, Knowles TP, Dobson CM, Buell AK, Galvagnion C. Flagmeier P, et al. Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10328-33. doi: 10.1073/pnas.1604645113. Epub 2016 Aug 29. Proc Natl Acad Sci U S A. 2016. PMID: 27573854 Free PMC article.

8

Ultrasensitive Measurement of Ca²⁺ Influx into Lipid Vesicles Induced by Protein Aggregates.

Flagmeier P, De S, Wirthensohn DC, Lee SF, Vincke C, Muyldermans S, Knowles TPJ, Gandhi S, Dobson CM, Klenerman D. Flagmeier P, et al. Angew Chem Int Ed Engl. 2017 Jun 26;56(27):7750-7754. doi: 10.1002/anie.201700966. Epub 2017 May 5. Angew Chem Int Ed Engl. 2017. PMID: 28474754 Free PMC article.

9

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM. Perni M, et al. Among authors: flagmeier p. ACS Chem Biol. 2018 Aug 17;13(8):2308-2319. doi: 10.1021/acschembio.8b00466. Epub 2018 Jun 28. ACS Chem Biol. 2018. PMID: 29953201

10

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.

De S, Wirthensohn DC, Flagmeier P, Hughes C, Aprile FA, Ruggeri FS, Whiten DR, Emin D, Xia Z, Varela JA, Sormanni P, Kundel F, Knowles TPJ, Dobson CM, Bryant C, Vendruscolo M, Klenerman D. De S, et al. Among authors: flagmeier p. Nat Commun. 2019 Apr 4;10(1):1541. doi: 10.1038/s41467-019-09477-3. Nat Commun. 2019. PMID: 30948723 Free PMC article.

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