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Ultradeep single-molecule real-time sequencing of HIV envelope reveals complete compartmentalization of highly macrophage-tropic R5 proviral variants in brain and CXCR4-using variants in immune and peripheral tissues.
Brese RL, Gonzalez-Perez MP, Koch M, O'Connell O, Luzuriaga K, Somasundaran M, Clapham PR, Dollar JJ, Nolan DJ, Rose R, Lamers SL. Brese RL, et al. Among authors: gonzalez perez mp. J Neurovirol. 2018 Aug;24(4):439-453. doi: 10.1007/s13365-018-0633-5. Epub 2018 Apr 23. J Neurovirol. 2018. PMID: 29687407 Free PMC article.
HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded.
Quitadamo B, Peters PJ, Repik A, O'Connell O, Mou Z, Koch M, Somasundaran M, Brody R, Luzuriaga K, Wallace A, Wang S, Lu S, McCauley S, Luban J, Duenas-Decamp M, Gonzalez-Perez MP, Clapham PR. Quitadamo B, et al. Among authors: gonzalez perez mp. J Virol. 2018 Jan 2;92(2):e00841-17. doi: 10.1128/JVI.00841-17. Print 2018 Jan 15. J Virol. 2018. PMID: 29118121 Free PMC article.
Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism.
O'Connell O, Repik A, Reeves JD, Gonzalez-Perez MP, Quitadamo B, Anton ED, Duenas-Decamp M, Peters P, Lin R, Zolla-Pazner S, Corti D, Wallace A, Wang S, Kong XP, Lu S, Clapham PR. O'Connell O, et al. Among authors: gonzalez perez mp. J Virol. 2013 Jan;87(1):187-98. doi: 10.1128/JVI.01834-12. Epub 2012 Oct 10. J Virol. 2013. PMID: 23055568 Free PMC article.
15 results