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Inhibition of lysine methyltransferase G9a/GLP reinstates long-term synaptic plasticity and synaptic tagging/capture by facilitating protein synthesis in the hippocampal CA1 area of APP/PS1 mouse model of Alzheimer's disease.
Han JLT, Pang KKL, Ang SRX, Sharma M, Sajikumar S. Han JLT, et al. Among authors: pang kkl. Transl Neurodegener. 2021 Jun 29;10(1):23. doi: 10.1186/s40035-021-00247-0. Transl Neurodegener. 2021. PMID: 34187583 Free PMC article. No abstract available.
Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid-beta 1-42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons.
Singh AK, Neo SH, Liwang C, Pang KKL, Leng JCK, Sinha SH, Shetty MS, Vasudevan M, Rao VJ, Joshi I, Eswaramoorthy M, Pavon MV, Sheila AR, Navakkode S, Kundu TK, Sajikumar S. Singh AK, et al. Among authors: pang kkl. Aging Cell. 2022 Sep;21(9):e13675. doi: 10.1111/acel.13675. Epub 2022 Aug 12. Aging Cell. 2022. PMID: 35962576 Free PMC article.