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Lipoprotein lipase is active as a monomer.
Beigneux AP, Allan CM, Sandoval NP, Cho GW, Heizer PJ, Jung RS, Stanhope KL, Havel PJ, Birrane G, Meiyappan M, Gill JE 4th, Murakami M, Miyashita K, Nakajima K, Ploug M, Fong LG, Young SG. Beigneux AP, et al. Among authors: jung rs. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6319-6328. doi: 10.1073/pnas.1900983116. Epub 2019 Mar 8. Proc Natl Acad Sci U S A. 2019. PMID: 30850549 Free PMC article.
Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL.
Hu X, Sleeman MW, Miyashita K, Linton MF, Allan CM, He C, Larsson M, Tu Y, Sandoval NP, Jung RS, Mapar A, Machida T, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP. Hu X, et al. Among authors: jung rs. J Lipid Res. 2017 Jan;58(1):208-215. doi: 10.1194/jlr.M072462. Epub 2016 Nov 15. J Lipid Res. 2017. PMID: 27875259 Free PMC article.
An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner.
Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Morales JE, Sajti E, Troutman TD, Saunders TL, Cusanovich DA, Beigneux AP, Romanoski CE, Fong LG, Young SG. Allan CM, et al. Among authors: jung rs. J Lipid Res. 2019 Apr;60(4):869-879. doi: 10.1194/jlr.M091322. Epub 2018 Dec 31. J Lipid Res. 2019. PMID: 30598475 Free PMC article.
An LPL-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1.
Allan CM, Larsson M, Hu X, He C, Jung RS, Mapar A, Voss C, Miyashita K, Machida T, Murakami M, Nakajima K, Bensadoun A, Ploug M, Fong LG, Young SG, Beigneux AP. Allan CM, et al. Among authors: jung rs. J Lipid Res. 2016 Oct;57(10):1889-1898. doi: 10.1194/jlr.M070813. Epub 2016 Aug 5. J Lipid Res. 2016. PMID: 27494936 Free PMC article.
29 results