Escandon E - Search Results

1

Pharmacokinetic Properties of Humanized IgG1 and IgG4 Antibodies in Preclinical Species: Translational Evaluation.

Tabrizi M, Neupane D, Elie SE, Shankaran H, Juan V, Zhang S, Hseih S, Fayadat-Dilman L, Zhang D, Song Y, Ganti V, Judo M, Spellman D, Seghezzi W, Escandon E. Tabrizi M, et al. Among authors: escandon e. AAPS J. 2019 Mar 13;21(3):39. doi: 10.1208/s12248-019-0304-3. AAPS J. 2019. PMID: 30868312

2

A capillary electrophoresis based approach for the identification of anti-drug antibodies against camelid VHH biologics (Nanobodies®).

Wiswell D, Neupane D, Chen M, Bowman EP, Linn D, Sawant A, Chackerian A, Zhang S, Escandón E. Wiswell D, et al. Among authors: escandon e. J Pharmacol Toxicol Methods. 2020 May-Jun;103:106872. doi: 10.1016/j.vascn.2020.106872. Epub 2020 May 7. J Pharmacol Toxicol Methods. 2020. PMID: 32387500

3

The Role of Anti-Drug Antibodies in the Pharmacokinetics, Disposition, Target Engagement, and Efficacy of a GITR Agonist Monoclonal Antibody in Mice.

Brunn ND, Mauze S, Gu D, Wiswell D, Ueda R, Hodges D, Beebe AM, Zhang S, Escandón E. Brunn ND, et al. Among authors: escandon e. J Pharmacol Exp Ther. 2016 Mar;356(3):574-86. doi: 10.1124/jpet.115.229864. Epub 2015 Dec 15. J Pharmacol Exp Ther. 2016. PMID: 26669426

4

Effects of PEGylation and immune complex formation on the pharmacokinetics and biodistribution of recombinant interleukin 10 in mice.

Alvarez HM, So OY, Hsieh S, Shinsky-Bjorde N, Ma H, Song Y, Pang Y, Marian M, Escandón E. Alvarez HM, et al. Among authors: escandon e. Drug Metab Dispos. 2012 Feb;40(2):360-73. doi: 10.1124/dmd.111.042531. Epub 2011 Nov 14. Drug Metab Dispos. 2012. PMID: 22083830

5

Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor.

Lin YS, Nguyen C, Mendoza JL, Escandon E, Fei D, Meng YG, Modi NB. Lin YS, et al. Among authors: escandon e. J Pharmacol Exp Ther. 1999 Jan;288(1):371-8. J Pharmacol Exp Ther. 1999. PMID: 9862791

6

Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper.

Kraynov E, Kamath AV, Walles M, Tarcsa E, Deslandes A, Iyer RA, Datta-Mannan A, Sriraman P, Bairlein M, Yang JJ, Barfield M, Xiao G, Escandon E, Wang W, Rock DA, Chemuturi NV, Moore DJ. Kraynov E, et al. Among authors: escandon e. Drug Metab Dispos. 2016 May;44(5):617-23. doi: 10.1124/dmd.115.068049. Epub 2015 Dec 15. Drug Metab Dispos. 2016. PMID: 26669328 Review.

7

Characterization of a CC49-based single-chain fragment-beta-lactamase fusion protein for antibody-directed enzyme prodrug therapy (ADEPT).

Alderson RF, Toki BE, Roberge M, Geng W, Basler J, Chin R, Liu A, Ueda R, Hodges D, Escandon E, Chen T, Kanavarioti T, Babé L, Senter PD, Fox JA, Schellenberger V. Alderson RF, et al. Among authors: escandon e. Bioconjug Chem. 2006 Mar-Apr;17(2):410-8. doi: 10.1021/bc0503521. Bioconjug Chem. 2006. PMID: 16536473

8

Omomyc Reveals New Mechanisms To Inhibit the MYC Oncogene.

Demma MJ, Mapelli C, Sun A, Bodea S, Ruprecht B, Javaid S, Wiswell D, Muise E, Chen S, Zelina J, Orvieto F, Santoprete A, Altezza S, Tucci F, Escandon E, Hall B, Ray K, Walji A, O'Neil J. Demma MJ, et al. Among authors: escandon e. Mol Cell Biol. 2019 Oct 28;39(22):e00248-19. doi: 10.1128/MCB.00248-19. Print 2019 Nov 15. Mol Cell Biol. 2019. PMID: 31501275 Free PMC article.

9

Characterizing the Pharmacokinetics and Biodistribution of Therapeutic Proteins: An Industry White Paper.

Ball K, Bruin G, Escandón E, Funk C, Pereira JNS, Yang TY, Yu H. Ball K, et al. Among authors: escandon e. Drug Metab Dispos. 2022 Jun;50(6):858-866. doi: 10.1124/dmd.121.000463. Epub 2022 Feb 11. Drug Metab Dispos. 2022. PMID: 35149542 Review.

10

Tissue distribution, stability, and pharmacokinetics of Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in human colon carcinoma COLO205 tumor-bearing nude mice.

Xiang H, Nguyen CB, Kelley SK, Dybdal N, Escandón E. Xiang H, et al. Among authors: escandon e. Drug Metab Dispos. 2004 Nov;32(11):1230-8. doi: 10.1124/dmd.104.000323. Epub 2004 Jul 28. Drug Metab Dispos. 2004. PMID: 15282212

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