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IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells.
Davidson DJ, Currie AJ, Bowdish DM, Brown KL, Rosenberger CM, Ma RC, Bylund J, Campsall PA, Puel A, Picard C, Casanova JL, Turvey SE, Hancock RE, Devon RS, Speert DP. Davidson DJ, et al. Among authors: casanova jl. J Immunol. 2006 Dec 1;177(11):8202-11. doi: 10.4049/jimmunol.177.11.8202. J Immunol. 2006. PMID: 17114497 Free PMC article.
The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88.
He B, Santamaria R, Xu W, Cols M, Chen K, Puga I, Shan M, Xiong H, Bussel JB, Chiu A, Puel A, Reichenbach J, Marodi L, Döffinger R, Vasconcelos J, Issekutz A, Krause J, Davies G, Li X, Grimbacher B, Plebani A, Meffre E, Picard C, Cunningham-Rundles C, Casanova JL, Cerutti A. He B, et al. Among authors: casanova jl. Nat Immunol. 2010 Sep;11(9):836-45. doi: 10.1038/ni.1914. Epub 2010 Aug 1. Nat Immunol. 2010. PMID: 20676093 Free PMC article.
TLR-mediated inflammatory responses to Streptococcus pneumoniae are highly dependent on surface expression of bacterial lipoproteins.
Tomlinson G, Chimalapati S, Pollard T, Lapp T, Cohen J, Camberlein E, Stafford S, Periselneris J, Aldridge C, Vollmer W, Picard C, Casanova JL, Noursadeghi M, Brown J. Tomlinson G, et al. Among authors: casanova jl. J Immunol. 2014 Oct 1;193(7):3736-45. doi: 10.4049/jimmunol.1401413. Epub 2014 Aug 29. J Immunol. 2014. PMID: 25172490 Free PMC article. Clinical Trial.
Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms.
Pelka K, Phulphagar K, Zimmermann J, Stahl R, Schmid-Burgk JL, Schmidt T, Spille JH, Labzin LI, Agrawal S, Kandimalla ER, Casanova JL, Hornung V, Marshak-Rothstein A, Höning S, Latz E. Pelka K, et al. Among authors: casanova jl. J Immunol. 2014 Oct 1;193(7):3257-61. doi: 10.4049/jimmunol.1301886. Epub 2014 Sep 3. J Immunol. 2014. PMID: 25187660 Free PMC article.
DOCK8 Drives Src-Dependent NK Cell Effector Function.
Kearney CJ, Vervoort SJ, Ramsbottom KM, Freeman AJ, Michie J, Peake J, Casanova JL, Picard C, Tangye SG, Ma CS, Johnstone RW, Randall KL, Oliaro J. Kearney CJ, et al. Among authors: casanova jl. J Immunol. 2017 Aug 9:ji1700751. doi: 10.4049/jimmunol.1700751. Online ahead of print. J Immunol. 2017. PMID: 28794229
Lessons learned from the study of human inborn errors of innate immunity.
Bucciol G, Moens L, Bosch B, Bossuyt X, Casanova JL, Puel A, Meyts I. Bucciol G, et al. Among authors: casanova jl. J Allergy Clin Immunol. 2019 Feb;143(2):507-527. doi: 10.1016/j.jaci.2018.07.013. Epub 2018 Aug 1. J Allergy Clin Immunol. 2019. PMID: 30075154 Free PMC article. Review.
Human inborn errors of immunity: An expanding universe.
Notarangelo LD, Bacchetta R, Casanova JL, Su HC. Notarangelo LD, et al. Among authors: casanova jl. Sci Immunol. 2020 Jul 10;5(49):eabb1662. doi: 10.1126/sciimmunol.abb1662. Sci Immunol. 2020. PMID: 32651211 Free PMC article. Review.
1,065 results