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Preservation of circadian rhythms by the protein folding chaperone, BiP.
Pickard A, Chang J, Alachkar N, Calverley B, Garva R, Arvan P, Meng QJ, Kadler KE. Pickard A, et al. FASEB J. 2019 Jun;33(6):7479-7489. doi: 10.1096/fj.201802366RR. Epub 2019 Mar 19. FASEB J. 2019. PMID: 30888851 Free PMC article.
The significance of these findings was explored in tendon, where we showed that BiP expression is ramped preemptively prior to a surge in collagen synthesis at night, thereby preventing protein misfolding and ER stress. ...Thus, targeting ER stress could be used to modulat …
The significance of these findings was explored in tendon, where we showed that BiP expression is ramped preemptively prior to a surg …
Circadian control of the secretory pathway maintains collagen homeostasis.
Chang J, Garva R, Pickard A, Yeung CC, Mallikarjun V, Swift J, Holmes DF, Calverley B, Lu Y, Adamson A, Raymond-Hayling H, Jensen O, Shearer T, Meng QJ, Kadler KE. Chang J, et al. Among authors: pickard a. Nat Cell Biol. 2020 Jan;22(1):74-86. doi: 10.1038/s41556-019-0441-z. Epub 2020 Jan 6. Nat Cell Biol. 2020. PMID: 31907414 Free PMC article.
Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts.
Yeung CC, Garva R, Pickard A, Lu Y, Mallikarjun V, Swift J, Taylor SH, Rai J, Eyre DR, Chaturvedi M, Itoh Y, Meng QJ, Mauch C, Zigrino P, Kadler KE. Yeung CC, et al. Among authors: pickard a. Matrix Biol. 2023 Dec;124:8-22. doi: 10.1016/j.matbio.2023.10.002. Epub 2023 Oct 31. Matrix Biol. 2023. PMID: 37913834 Free article.
335 results