Santofimia-Castaño P - Search Results

1

Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis.

Santofimia-Castaño P, Xia Y, Lan W, Zhou Z, Huang C, Peng L, Soubeyran P, Velázquez-Campoy A, Abián O, Rizzuti B, Neira JL, Iovanna J. Santofimia-Castaño P, et al. J Clin Invest. 2019 Mar 28;129(6):2500-2513. doi: 10.1172/JCI127223. J Clin Invest. 2019. PMID: 30920390 Free PMC article.

2

Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B.

Santofimia-Castaño P, Rizzuti B, Pey ÁL, Soubeyran P, Vidal M, Urrutia R, Iovanna JL, Neira JL. Santofimia-Castaño P, et al. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6332-E6341. doi: 10.1073/pnas.1619932114. Epub 2017 Jul 18. Proc Natl Acad Sci U S A. 2017. PMID: 28720707 Free PMC article.

3

Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1).

Santofimia-Castaño P, Rizzuti B, Abián O, Velázquez-Campoy A, Iovanna JL, Neira JL. Santofimia-Castaño P, et al. Biochim Biophys Acta Gen Subj. 2018 Jun;1862(6):1283-1295. doi: 10.1016/j.bbagen.2018.03.009. Epub 2018 Mar 10. Biochim Biophys Acta Gen Subj. 2018. PMID: 29530795

4

E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments.

Lan W, Bian B, Xia Y, Dou S, Gayet O, Bigonnet M, Santofimia-Castaño P, Cong M, Peng L, Dusetti N, Iovanna J. Lan W, et al. Sci Rep. 2018 May 29;8(1):8330. doi: 10.1038/s41598-018-26613-z. Sci Rep. 2018. PMID: 29844366 Free PMC article.

5

α-lipoic acid reduces postreperfusion syndrome in human liver transplantation - a pilot study.

Casciato P, Ambrosi N, Caro F, Vazquez M, Müllen E, Gadano A, de Santibañes E, de Santibañes M, Zandomeni M, Chahdi M, Lazarte JC, Biagiola DA, Iaquinandi JC, Santofimia-Castaño P, Iovanna J, Incardona C, Chuluyan E. Casciato P, et al. Transpl Int. 2018 Dec;31(12):1357-1368. doi: 10.1111/tri.13314. Epub 2018 Jul 20. Transpl Int. 2018. PMID: 29974521 Free article. Clinical Trial.

6

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis.

Santofimia-Castaño P, Lan W, Bintz J, Gayet O, Carrier A, Lomberk G, Neira JL, González A, Urrutia R, Soubeyran P, Iovanna J. Santofimia-Castaño P, et al. Sci Rep. 2018 Nov 19;8(1):16999. doi: 10.1038/s41598-018-35020-3. Sci Rep. 2018. PMID: 30451898 Free PMC article.

7

Melatonin induces reactive oxygen species generation and changes in glutathione levels and reduces viability in human pancreatic stellate cells.

Estaras M, Moreno N, Santofimia-Castaño P, Martinez-Morcillo S, Roncero V, Blanco G, Lopez D, Fernandez-Bermejo M, Mateos JM, Iovanna JL, Salido GM, Gonzalez A. Estaras M, et al. J Physiol Biochem. 2019 Jun;75(2):185-197. doi: 10.1007/s13105-019-00671-x. Epub 2019 Mar 13. J Physiol Biochem. 2019. PMID: 30868511

8

Dendrimers as Competitors of Protein-Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1.

Neira JL, Correa J, Rizzuti B, Santofimia-Castaño P, Abian O, Velázquez-Campoy A, Fernandez-Megia E, Iovanna JL. Neira JL, et al. Biomacromolecules. 2019 Jul 8;20(7):2567-2576. doi: 10.1021/acs.biomac.9b00378. Epub 2019 Jun 24. Biomacromolecules. 2019. PMID: 31181156

9

Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm.

Santofimia-Castaño P, Rizzuti B, Xia Y, Abian O, Peng L, Velázquez-Campoy A, Iovanna JL, Neira JL. Santofimia-Castaño P, et al. Mol Cell Oncol. 2019 May 16;6(5):e1612678. doi: 10.1080/23723556.2019.1612678. eCollection 2019. Mol Cell Oncol. 2019. PMID: 31528692 Free PMC article.

10

Targeting intrinsically disordered proteins involved in cancer.

Santofimia-Castaño P, Rizzuti B, Xia Y, Abian O, Peng L, Velázquez-Campoy A, Neira JL, Iovanna J. Santofimia-Castaño P, et al. Cell Mol Life Sci. 2020 May;77(9):1695-1707. doi: 10.1007/s00018-019-03347-3. Epub 2019 Oct 30. Cell Mol Life Sci. 2020. PMID: 31667555 Free PMC article. Review.

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