Born DA - Search Results

1

Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects.

Nguyen PA, Born DA, Deaton AM, Nioi P, Ward LD. Nguyen PA, et al. Among authors: born da. Nat Commun. 2019 Apr 5;10(1):1579. doi: 10.1038/s41467-019-09407-3. Nat Commun. 2019. PMID: 30952858 Free PMC article.

2

Author Correction: Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects.

Nguyen PA, Born DA, Deaton AM, Nioi P, Ward LD. Nguyen PA, et al. Among authors: born da. Nat Commun. 2019 May 8;10(1):2132. doi: 10.1038/s41467-019-10237-6. Nat Commun. 2019. PMID: 31068582 Free PMC article.

3

Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity.

Yu Y, Leete TC, Born DA, Young L, Barrera LA, Lee SJ, Rees HA, Ciaramella G, Gaudelli NM. Yu Y, et al. Among authors: born da. Nat Commun. 2020 Apr 28;11(1):2052. doi: 10.1038/s41467-020-15887-5. Nat Commun. 2020. PMID: 32345976 Free PMC article.

4

Directed evolution of adenine base editors with increased activity and therapeutic application.

Gaudelli NM, Lam DK, Rees HA, Solá-Esteves NM, Barrera LA, Born DA, Edwards A, Gehrke JM, Lee SJ, Liquori AJ, Murray R, Packer MS, Rinaldi C, Slaymaker IM, Yen J, Young LE, Ciaramella G. Gaudelli NM, et al. Among authors: born da. Nat Biotechnol. 2020 Jul;38(7):892-900. doi: 10.1038/s41587-020-0491-6. Epub 2020 Apr 13. Nat Biotechnol. 2020. PMID: 32284586

5

Rationally Designed Base Editors for Precise Editing of the Sickle Cell Disease Mutation.

Chu SH, Packer M, Rees H, Lam D, Yu Y, Marshall J, Cheng LI, Lam D, Olins J, Ran FA, Liquori A, Gantzer B, Decker J, Born D, Barrera L, Hartigan A, Gaudelli N, Ciaramella G, Slaymaker IM. Chu SH, et al. CRISPR J. 2021 Apr;4(2):169-177. doi: 10.1089/crispr.2020.0144. CRISPR J. 2021. PMID: 33876959

6

Structural basis for methylphosphonate biosynthesis.

Born DA, Ulrich EC, Ju KS, Peck SC, van der Donk WA, Drennan CL. Born DA, et al. Science. 2017 Dec 8;358(6368):1336-1339. doi: 10.1126/science.aao3435. Science. 2017. PMID: 29217579 Free PMC article.

7

Structural insight into G-protein chaperone-mediated maturation of a bacterial adenosylcobalamin-dependent mutase.

Vaccaro FA, Faber DA, Andree GA, Born DA, Kang G, Fonseca DR, Jost M, Drennan CL. Vaccaro FA, et al. Among authors: born da. J Biol Chem. 2023 Sep;299(9):105109. doi: 10.1016/j.jbc.2023.105109. Epub 2023 Jul 28. J Biol Chem. 2023. PMID: 37517695 Free PMC article.

8

Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase.

Harris NC, Born DA, Cai W, Huang Y, Martin J, Khalaf R, Drennan CL, Zhang W. Harris NC, et al. Among authors: born da. Angew Chem Int Ed Engl. 2018 Jul 26;57(31):9707-9710. doi: 10.1002/anie.201804307. Epub 2018 Jul 3. Angew Chem Int Ed Engl. 2018. PMID: 29906336 Free PMC article.

9

Structural Basis for Substrate Specificity in Adenosylcobalamin-dependent Isobutyryl-CoA Mutase and Related Acyl-CoA Mutases.

Jost M, Born DA, Cracan V, Banerjee R, Drennan CL. Jost M, et al. Among authors: born da. J Biol Chem. 2015 Nov 6;290(45):26882-26898. doi: 10.1074/jbc.M115.676890. Epub 2015 Aug 28. J Biol Chem. 2015. PMID: 26318610 Free PMC article.

10

Structure of metallochaperone in complex with the cobalamin-binding domain of its target mutase provides insight into cofactor delivery.

Vaccaro FA, Born DA, Drennan CL. Vaccaro FA, et al. Among authors: born da. Proc Natl Acad Sci U S A. 2023 Feb 21;120(8):e2214085120. doi: 10.1073/pnas.2214085120. Epub 2023 Feb 14. Proc Natl Acad Sci U S A. 2023. PMID: 36787360 Free PMC article.

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