Manville RW - Search Results

1

Teamwork: Ion channels and transporters join forces in the brain.

Manville RW, Abbott GW. Manville RW, et al. Neuropharmacology. 2019 Dec 15;161:107601. doi: 10.1016/j.neuropharm.2019.04.007. Epub 2019 Apr 5. Neuropharmacology. 2019. PMID: 30959022 Free PMC article. Review.

2

SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore.

Manville RW, Neverisky DL, Abbott GW. Manville RW, et al. Biophys J. 2017 Aug 8;113(3):613-626. doi: 10.1016/j.bpj.2017.06.055. Biophys J. 2017. PMID: 28793216 Free PMC article.

3

Direct neurotransmitter activation of voltage-gated potassium channels.

Manville RW, Papanikolaou M, Abbott GW. Manville RW, et al. Nat Commun. 2018 May 10;9(1):1847. doi: 10.1038/s41467-018-04266-w. Nat Commun. 2018. PMID: 29748663 Free PMC article.

4

Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels.

Manville RW, Abbott GW. Manville RW, et al. Mol Pharmacol. 2018 Oct;94(4):1155-1163. doi: 10.1124/mol.118.112953. Epub 2018 Jul 18. Mol Pharmacol. 2018. PMID: 30021858 Free PMC article.

5

Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket.

Manville RW, Abbott GW. Manville RW, et al. Nat Commun. 2018 Sep 21;9(1):3845. doi: 10.1038/s41467-018-06339-2. Nat Commun. 2018. PMID: 30242262 Free PMC article.

6

Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation.

De Silva AM, Manville RW, Abbott GW. De Silva AM, et al. Among authors: manville rw. Sci Adv. 2018 Nov 14;4(11):eaav0824. doi: 10.1126/sciadv.aav0824. eCollection 2018 Nov. Sci Adv. 2018. PMID: 30443601 Free PMC article.

7

Cilantro leaf harbors a potent potassium channel-activating anticonvulsant.

Manville RW, Abbott GW. Manville RW, et al. FASEB J. 2019 Oct;33(10):11349-11363. doi: 10.1096/fj.201900485R. Epub 2019 Jul 16. FASEB J. 2019. PMID: 31311306 Free PMC article.

8

KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines.

Manville RW, van der Horst J, Redford KE, Katz BB, Jepps TA, Abbott GW. Manville RW, et al. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21236-21245. doi: 10.1073/pnas.1907511116. Epub 2019 Sep 30. Proc Natl Acad Sci U S A. 2019. PMID: 31570602 Free PMC article.

9

In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner.

Manville RW, Abbott GW. Manville RW, et al. Commun Biol. 2019 Nov 1;2:401. doi: 10.1038/s42003-019-0648-3. eCollection 2019. Commun Biol. 2019. PMID: 31701029 Free PMC article.

10

M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone Body β-Hydroxybutyrate.

Manville RW, Papanikolaou M, Abbott GW. Manville RW, et al. J Pharmacol Exp Ther. 2020 Feb;372(2):148-156. doi: 10.1124/jpet.119.263350. Epub 2019 Nov 22. J Pharmacol Exp Ther. 2020. PMID: 31757819 Free PMC article.

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