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An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity.
Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Prévost J, Tolbert WD, Lu H, Medjahed H, Gendron-Lepage G, Ortega Delgado GG, Kirk S, Melillo B, Mothes W, Sodroski J, Smith AB 3rd, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, Munro JB. Alsahafi N, et al. Among authors: wu x. Cell Host Microbe. 2019 Apr 10;25(4):578-587.e5. doi: 10.1016/j.chom.2019.03.002. Cell Host Microbe. 2019. PMID: 30974085 Free PMC article.
Broad HIV-1 neutralization mediated by CD4-binding site antibodies.
Li Y, Migueles SA, Welcher B, Svehla K, Phogat A, Louder MK, Wu X, Shaw GM, Connors M, Wyatt RT, Mascola JR. Li Y, et al. Among authors: wu x. Nat Med. 2007 Sep;13(9):1032-4. doi: 10.1038/nm1624. Epub 2007 Aug 26. Nat Med. 2007. PMID: 17721546 Free PMC article.
Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
Chen L, Kwon YD, Zhou T, Wu X, O'Dell S, Cavacini L, Hessell AJ, Pancera M, Tang M, Xu L, Yang ZY, Zhang MY, Arthos J, Burton DR, Dimitrov DS, Nabel GJ, Posner MR, Sodroski J, Wyatt R, Mascola JR, Kwong PD. Chen L, et al. Among authors: wu x. Science. 2009 Nov 20;326(5956):1123-7. doi: 10.1126/science.1175868. Science. 2009. PMID: 19965434 Free PMC article.
Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01.
Zhou T, Georgiev I, Wu X, Yang ZY, Dai K, Finzi A, Kwon YD, Scheid JF, Shi W, Xu L, Yang Y, Zhu J, Nussenzweig MC, Sodroski J, Shapiro L, Nabel GJ, Mascola JR, Kwong PD. Zhou T, et al. Among authors: wu x. Science. 2010 Aug 13;329(5993):811-7. doi: 10.1126/science.1192819. Epub 2010 Jul 8. Science. 2010. PMID: 20616231 Free PMC article.
Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1.
Wu X, Yang ZY, Li Y, Hogerkorp CM, Schief WR, Seaman MS, Zhou T, Schmidt SD, Wu L, Xu L, Longo NS, McKee K, O'Dell S, Louder MK, Wycuff DL, Feng Y, Nason M, Doria-Rose N, Connors M, Kwong PD, Roederer M, Wyatt RT, Nabel GJ, Mascola JR. Wu X, et al. Among authors: wu l. Science. 2010 Aug 13;329(5993):856-61. doi: 10.1126/science.1187659. Epub 2010 Jul 8. Science. 2010. PMID: 20616233 Free PMC article.
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops.
Kwon YD, Finzi A, Wu X, Dogo-Isonagie C, Lee LK, Moore LR, Schmidt SD, Stuckey J, Yang Y, Zhou T, Zhu J, Vicic DA, Debnath AK, Shapiro L, Bewley CA, Mascola JR, Sodroski JG, Kwong PD. Kwon YD, et al. Among authors: wu x. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5663-8. doi: 10.1073/pnas.1112391109. Epub 2012 Mar 26. Proc Natl Acad Sci U S A. 2012. PMID: 22451932 Free PMC article.
Anti-HIV B Cell lines as candidate vaccine biosensors.
Ota T, Doyle-Cooper C, Cooper AB, Huber M, Falkowska E, Doores KJ, Hangartner L, Le K, Sok D, Jardine J, Lifson J, Wu X, Mascola JR, Poignard P, Binley JM, Chakrabarti BK, Schief WR, Wyatt RT, Burton DR, Nemazee D. Ota T, et al. Among authors: wu x. J Immunol. 2012 Nov 15;189(10):4816-24. doi: 10.4049/jimmunol.1202165. Epub 2012 Oct 12. J Immunol. 2012. PMID: 23066156 Free PMC article.
Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies.
Kepler TB, Liao HX, Alam SM, Bhaskarabhatla R, Zhang R, Yandava C, Stewart S, Anasti K, Kelsoe G, Parks R, Lloyd KE, Stolarchuk C, Pritchett J, Solomon E, Friberg E, Morris L, Karim SS, Cohen MS, Walter E, Moody MA, Wu X, Altae-Tran HR, Georgiev IS, Kwong PD, Boyd SD, Fire AZ, Mascola JR, Haynes BF. Kepler TB, et al. Among authors: wu x. Cell Host Microbe. 2014 Sep 10;16(3):304-13. doi: 10.1016/j.chom.2014.08.006. Cell Host Microbe. 2014. PMID: 25211073 Free PMC article.
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