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Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5'-exonuclease.
Kumar P, Degaonkar R, Guenther DC, Abramov M, Schepers G, Capobianco M, Jiang Y, Harp J, Kaittanis C, Janas MM, Castoreno A, Zlatev I, Schlegel MK, Herdewijn P, Egli M, Manoharan M. Kumar P, et al. Nucleic Acids Res. 2020 May 7;48(8):4028-4040. doi: 10.1093/nar/gkaa125. Nucleic Acids Res. 2020. PMID: 32170309 Free PMC article.
siRNAs containing 2'-fluorinated Northern-methanocarbacyclic (2'-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2'-F-NMC NTPs.
Akabane-Nakata M, Erande ND, Kumar P, Degaonkar R, Gilbert JA, Qin J, Mendez M, Woods LB, Jiang Y, Janas MM, O'Flaherty DK, Zlatev I, Schlegel MK, Matsuda S, Egli M, Manoharan M. Akabane-Nakata M, et al. Among authors: kumar p. Nucleic Acids Res. 2021 Mar 18;49(5):2435-2449. doi: 10.1093/nar/gkab050. Nucleic Acids Res. 2021. PMID: 33577685 Free PMC article.
Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.
Jahns H, Degaonkar R, Podbevsek P, Gupta S, Bisbe A, Aluri K, Szeto J, Kumar P, LeBlanc S, Racie T, Brown CR, Castoreno A, Guenther DC, Jadhav V, Maier MA, Plavec J, Egli M, Manoharan M, Zlatev I. Jahns H, et al. Among authors: kumar p. Nucleic Acids Res. 2021 Oct 11;49(18):10250-10264. doi: 10.1093/nar/gkab724. Nucleic Acids Res. 2021. PMID: 34508350 Free PMC article.
Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA.
Sau SP, Kumar P, Anderson BA, Østergaard ME, Deobald L, Paszczynski A, Sharma PK, Hrdlicka PJ. Sau SP, et al. Among authors: kumar p. Chem Commun (Camb). 2009 Nov 28;(44):6756-8. doi: 10.1039/b917312a. Epub 2009 Oct 12. Chem Commun (Camb). 2009. PMID: 19885469 Free PMC article.
Condensing the information in DNA with double-headed nucleotides.
Hornum M, Sharma PK, Reslow-Jacobsen C, Kumar P, Petersen M, Nielsen P. Hornum M, et al. Among authors: kumar p. Chem Commun (Camb). 2017 Aug 29;53(70):9717-9720. doi: 10.1039/c7cc05047j. Chem Commun (Camb). 2017. PMID: 28820207
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