McConnell N - Search Results

1

Microwave-assisted green synthesis of anilines, phenols, and benzenediamines without transition metals, ligands, or organic solvents.

McConnell N, Frett B, Li H. McConnell N, et al. Green Chem Lett Rev. 2018;11(3):286-295. doi: 10.1080/17518253.2018.1486464. Epub 2018 Jul 3. Green Chem Lett Rev. 2018. PMID: 30984284 Free PMC article.

2

Synthesis of Constrained Heterocycles Employing Two Post-Ugi Cyclization Methods for Rapid Library Generation with In Cellulo Activity.

McConnell N, Xu Z, Kumarasamy V, Sun D, Frett B, Li HY. McConnell N, et al. ChemistrySelect. 2017 Dec 11;2(35):11821-11825. doi: 10.1002/slct.201702179. Epub 2017 Dec 19. ChemistrySelect. 2017. PMID: 30140731 Free PMC article.

3

Selective, C-3 Friedel-Crafts acylation to generate functionally diverse, acetylated Imidazo[1,2-a]pyridine derivatives.

Frett B, McConnell N, Kharbanda A, Naresh G, Rounseville B, Warner C, Chang J, Debolske N, Li HY. Frett B, et al. Among authors: mcconnell n. Tetrahedron. 2018 Aug 30;74(35):4592-4600. doi: 10.1016/j.tet.2018.07.027. Epub 2018 Jul 17. Tetrahedron. 2018. PMID: 30344351 Free PMC article.

4

Rational Design, Synthesis and Biological Evaluation of Pyrimidine-4,6-diamine derivatives as Type-II inhibitors of FLT3 Selective Against c-KIT.

Bharate JB, McConnell N, Naresh G, Zhang L, Lakkaniga NR, Ding L, Shah NP, Frett B, Li HY. Bharate JB, et al. Among authors: mcconnell n. Sci Rep. 2018 Feb 27;8(1):3722. doi: 10.1038/s41598-018-21839-3. Sci Rep. 2018. PMID: 29487300 Free PMC article.

5

Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases.

Moccia M, Yang D, Lakkaniga NR, Frett B, McConnell N, Zhang L, Brescia A, Federico G, Zhang L, Salerno P, Santoro M, Li HY, Carlomagno F. Moccia M, et al. Among authors: mcconnell n. Sci Rep. 2021 Aug 9;11(1):16103. doi: 10.1038/s41598-021-95612-4. Sci Rep. 2021. PMID: 34373541 Free PMC article.

6

Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor.

Zhang L, Lakkaniga NR, Bharate JB, Mcconnell N, Wang X, Kharbanda A, Leung YK, Frett B, Shah NP, Li HY. Zhang L, et al. Among authors: mcconnell n. Eur J Med Chem. 2021 Dec 5;225:113776. doi: 10.1016/j.ejmech.2021.113776. Epub 2021 Aug 17. Eur J Med Chem. 2021. PMID: 34479037 Free PMC article.

7

Metal-free, efficient hydrazination of imidazo[1,2-a]pyridine with diethyl azodicarboxylate in neutral media.

Wang Y, Frett B, McConnell N, Li HY. Wang Y, et al. Among authors: mcconnell n. Org Biomol Chem. 2015 Mar 14;13(10):2958-64. doi: 10.1039/c4ob02284j. Org Biomol Chem. 2015. PMID: 25611884 Free PMC article.

8

Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors.

Frett B, McConnell N, Smith CC, Wang Y, Shah NP, Li HY. Frett B, et al. Among authors: mcconnell n. Eur J Med Chem. 2015 Apr 13;94:123-31. doi: 10.1016/j.ejmech.2015.02.052. Epub 2015 Feb 28. Eur J Med Chem. 2015. PMID: 25765758 Free PMC article.

9

Identification of pyrazine-based TrkA inhibitors: design, synthesis, evaluation, and computational modeling studies.

Frett B, McConnell N, Wang Y, Xu Z, Ambrose A, Li HY. Frett B, et al. Among authors: mcconnell n. Medchemcomm. 2014 Oct 1;5(10):1507-1514. doi: 10.1039/C4MD00251B. Epub 2014 Aug 11. Medchemcomm. 2014. PMID: 26843921 Free PMC article.

10

One-Pot Two-Step Multicomponent Process of Indole and Other Nitrogenous Heterocycles or Amines toward α-Oxo-acetamidines.

Martinez-Ariza G, McConnell N, Hulme C. Martinez-Ariza G, et al. Among authors: mcconnell n. Org Lett. 2016 Apr 15;18(8):1864-7. doi: 10.1021/acs.orglett.6b00634. Epub 2016 Mar 29. Org Lett. 2016. PMID: 27020621

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