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Page 1
Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice.
Lindén D, Ahnmark A, Pingitore P, Ciociola E, Ahlstedt I, Andréasson AC, Sasidharan K, Madeyski-Bengtson K, Zurek M, Mancina RM, Lindblom A, Bjursell M, Böttcher G, Ståhlman M, Bohlooly-Y M, Haynes WG, Carlsson B, Graham M, Lee R, Murray S, Valenti L, Bhanot S, Åkerblad P, Romeo S. Lindén D, et al. Among authors: pingitore p. Mol Metab. 2019 Apr;22:49-61. doi: 10.1016/j.molmet.2019.01.013. Epub 2019 Feb 5. Mol Metab. 2019. PMID: 30772256 Free PMC article.
The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids.
Prill S, Caddeo A, Baselli G, Jamialahmadi O, Dongiovanni P, Rametta R, Kanebratt KP, Pujia A, Pingitore P, Mancina RM, Lindén D, Whatling C, Janefeldt A, Kozyra M, Ingelman-Sundberg M, Valenti L, Andersson TB, Romeo S. Prill S, et al. Among authors: pingitore p. Sci Rep. 2019 Aug 12;9(1):11585. doi: 10.1038/s41598-019-47737-w. Sci Rep. 2019. PMID: 31406127 Free PMC article.
The role of PNPLA3 in health and disease.
Pingitore P, Romeo S. Pingitore P, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun;1864(6):900-906. doi: 10.1016/j.bbalip.2018.06.018. Epub 2018 Jun 20. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 29935383 Review.
PSD3 downregulation confers protection against fatty liver disease.
Mancina RM, Sasidharan K, Lindblom A, Wei Y, Ciociola E, Jamialahmadi O, Pingitore P, Andréasson AC, Pellegrini G, Baselli G, Männistö V, Pihlajamäki J, Kärjä V, Grimaudo S, Marini I, Maggioni M, Becattini B, Tavaglione F, Dix C, Castaldo M, Klein S, Perelis M, Pattou F, Thuillier D, Raverdy V, Dongiovanni P, Fracanzani AL, Stickel F, Hampe J, Buch S, Luukkonen PK, Prati D, Yki-Järvinen H, Petta S, Xing C, Schafmayer C, Aigner E, Datz C, Lee RG, Valenti L, Lindén D, Romeo S. Mancina RM, et al. Among authors: pingitore p. Nat Metab. 2022 Jan;4(1):60-75. doi: 10.1038/s42255-021-00518-0. Epub 2022 Jan 31. Nat Metab. 2022. PMID: 35102341 Free PMC article.
PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells.
Pirazzi C, Valenti L, Motta BM, Pingitore P, Hedfalk K, Mancina RM, Burza MA, Indiveri C, Ferro Y, Montalcini T, Maglio C, Dongiovanni P, Fargion S, Rametta R, Pujia A, Andersson L, Ghosal S, Levin M, Wiklund O, Iacovino M, Borén J, Romeo S. Pirazzi C, et al. Among authors: pingitore p. Hum Mol Genet. 2014 Aug 1;23(15):4077-85. doi: 10.1093/hmg/ddu121. Epub 2014 Mar 25. Hum Mol Genet. 2014. PMID: 24670599 Free PMC article.
PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis.
Pingitore P, Dongiovanni P, Motta BM, Meroni M, Lepore SM, Mancina RM, Pelusi S, Russo C, Caddeo A, Rossi G, Montalcini T, Pujia A, Wiklund O, Valenti L, Romeo S. Pingitore P, et al. Hum Mol Genet. 2016 Dec 1;25(23):5212-5222. doi: 10.1093/hmg/ddw341. Hum Mol Genet. 2016. PMID: 27742777 Free PMC article.
Discovery and Targeting of the Signaling Controls of PNPLA3 to Effectively Reduce Transcription, Expression, and Function in Pre-Clinical NAFLD/NASH Settings.
Schwartz BE, Rajagopal V, Smith C, Cohick E, Whissell G, Gamboa M, Pai R, Sigova A, Grossman I, Bumcrot D, Sasidharan K, Romeo S, Sehgal A, Pingitore P. Schwartz BE, et al. Among authors: pingitore p. Cells. 2020 Oct 7;9(10):2247. doi: 10.3390/cells9102247. Cells. 2020. PMID: 33036387 Free PMC article.
PNPLA3 148M Carriers with Inflammatory Bowel Diseases Have Higher Susceptibility to Hepatic Steatosis and Higher Liver Enzymes.
Mancina RM, Spagnuolo R, Milano M, Brogneri S, Morrone A, Cosco C, Lazzaro V, Russo C, Ferro Y, Pingitore P, Pujia A, Montalcini T, Doldo P, Garieri P, Piodi L, Caprioli F, Valenti L, Romeo S. Mancina RM, et al. Among authors: pingitore p. Inflamm Bowel Dis. 2016 Jan;22(1):134-40. doi: 10.1097/MIB.0000000000000569. Inflamm Bowel Dis. 2016. PMID: 26355465 Free PMC article.
30 results