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Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension.
Wang Z, Jiang X, Zhang X, Tian G, Yang R, Wu J, Zou X, Liu Z, Yang X, Wu C, Shi J, Li J, Suo J, Wang Y, Zhang R, Xu Z, Gong X, He Y, Zhu W, Aisa HA, Jiang H, Xu Y, Shen J. Wang Z, et al. Among authors: aisa ha. J Med Chem. 2019 May 23;62(10):4979-4990. doi: 10.1021/acs.jmedchem.9b00123. Epub 2019 May 8. J Med Chem. 2019. PMID: 31021628
Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: synthesis and in vitro biological evaluation. Part 1.
Bozorov K, Ma HR, Zhao JY, Zhao HQ, Chen H, Bobakulov K, Xin XL, Elmuradov B, Shakhidoyatov K, Aisa HA. Bozorov K, et al. Among authors: aisa ha. Eur J Med Chem. 2014 Sep 12;84:739-45. doi: 10.1016/j.ejmech.2014.07.065. Epub 2014 Jul 21. Eur J Med Chem. 2014. PMID: 25064350
Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2.
Xie Y, Yin W, Zhang Y, Shang W, Wang Z, Luan X, Tian G, Aisa HA, Xu Y, Xiao G, Li J, Jiang H, Zhang S, Zhang L, Xu HE, Shen J. Xie Y, et al. Among authors: aisa ha. Cell Res. 2021 Nov;31(11):1212-1214. doi: 10.1038/s41422-021-00570-1. Epub 2021 Sep 28. Cell Res. 2021. PMID: 34584244 Free PMC article. No abstract available.
330 results