Jiang X - Search Results

1

Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension.

Wang Z, Jiang X, Zhang X, Tian G, Yang R, Wu J, Zou X, Liu Z, Yang X, Wu C, Shi J, Li J, Suo J, Wang Y, Zhang R, Xu Z, Gong X, He Y, Zhu W, Aisa HA, Jiang H, Xu Y, Shen J. Wang Z, et al. Among authors: jiang x, jiang h. J Med Chem. 2019 May 23;62(10):4979-4990. doi: 10.1021/acs.jmedchem.9b00123. Epub 2019 May 8. J Med Chem. 2019. PMID: 31021628

2

Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.

Wang G, Liu Z, Chen T, Wang Z, Yang H, Zheng M, Ren J, Tian G, Yang X, Li L, Li J, Suo J, Zhang R, Jiang X, Terrett NK, Shen J, Xu Y, Jiang H. Wang G, et al. Among authors: jiang x, jiang h. J Med Chem. 2012 Dec 13;55(23):10540-50. doi: 10.1021/jm301159y. Epub 2012 Nov 19. J Med Chem. 2012. PMID: 23137303

3

Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.

Gong X, Wang G, Ren J, Liu Z, Wang Z, Chen T, Yang X, Jiang X, Shen J, Jiang H, Aisa HA, Xu Y, Li J. Gong X, et al. Among authors: jiang x, jiang h. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4944-7. doi: 10.1016/j.bmcl.2013.06.062. Epub 2013 Jun 29. Bioorg Med Chem Lett. 2013. PMID: 23867165

4

The selectivity and potency of the new PDE5 inhibitor TPN729MA.

Wang Z, Zhu D, Yang X, Li J, Jiang X, Tian G, Terrett NK, Jin J, Wu H, He Q, Yang B, Shen J. Wang Z, et al. Among authors: jiang x. J Sex Med. 2013 Nov;10(11):2790-7. doi: 10.1111/jsm.12285. Epub 2013 Aug 12. J Sex Med. 2013. PMID: 23937247

5

Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2.

Kong X, Chen L, Jiao L, Jiang X, Lian F, Lu J, Zhu K, Du D, Liu J, Ding H, Zhang N, Shen J, Zheng M, Chen K, Liu X, Jiang H, Luo C. Kong X, et al. Among authors: jiang x, jiang h. J Med Chem. 2014 Nov 26;57(22):9512-21. doi: 10.1021/jm501230c. Epub 2014 Nov 12. J Med Chem. 2014. PMID: 25369470

6

Design, synthesis, and pharmacological evaluation of highly potent and selective dipeptidyl peptidase-4 inhibitors.

Jiang T, Zhou Y, Zhu J, Chen Z, Sun P, Zhang Q, Wang Z, Shao Q, Jiang X, Li B, Wang H, Zhu W, Shen J. Jiang T, et al. Among authors: jiang x. Arch Pharm (Weinheim). 2015 Jun;348(6):399-407. doi: 10.1002/ardp.201500082. Epub 2015 Apr 14. Arch Pharm (Weinheim). 2015. PMID: 25871012

7

Design, Synthesis, and Pharmacological Evaluation of Fused β-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors.

Jiang T, Zhou Y, Chen Z, Sun P, Zhu J, Zhang Q, Wang Z, Shao Q, Jiang X, Li B, Chen K, Jiang H, Wang H, Zhu W, Shen J. Jiang T, et al. Among authors: jiang x, jiang h. ACS Med Chem Lett. 2015 Apr 8;6(5):602-6. doi: 10.1021/acsmedchemlett.5b00074. eCollection 2015 May 14. ACS Med Chem Lett. 2015. PMID: 26005541 Free PMC article.

8

Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review.

Xie Y, Ogah CA, Jiang X, Li J, Shen J. Xie Y, et al. Among authors: jiang x. Curr Drug Targets. 2016;17(13):1560-76. doi: 10.2174/1389450117666151209123751. Curr Drug Targets. 2016. PMID: 26648061 Review.

9

Synthesis, structure-activity relationships, and biological evaluation of a series of benzamides as potential multireceptor antipsychotics.

Yang F, Jiang X, Li J, Wang Y, Liu Y, Bi M, Wu C, Zhao Q, Chen W, Yin J, Zhang J, Xie Y, Hu T, Xu M, Guo S, Wang Z, He Y, Shen J. Yang F, et al. Among authors: jiang x. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3141-3147. doi: 10.1016/j.bmcl.2016.04.087. Epub 2016 Apr 30. Bioorg Med Chem Lett. 2016. PMID: 27173799

10

Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics.

Xiamuxi H, Wang Z, Li J, Wang Y, Wu C, Yang F, Jiang X, Liu Y, Zhao Q, Chen W, Zhang J, Xie Y, Hu T, Xu M, Guo S, Akber Aisa H, He Y, Shen J. Xiamuxi H, et al. Among authors: jiang x. Bioorg Med Chem. 2017 Sep 1;25(17):4904-4916. doi: 10.1016/j.bmc.2017.07.040. Epub 2017 Jul 24. Bioorg Med Chem. 2017. PMID: 28774576

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